Modern Tools for the Synthesis of Complex Bioactive Molecules (ePub)
(Sprache: Englisch)
All the latest tools needed to plan and perform the synthesis
of complex bioactive molecules
Focusing on organic, organometallic, and bio-oriented processes,
this book explores the impact and use of the latest synthetic tools
for the synthesis of...
of complex bioactive molecules
Focusing on organic, organometallic, and bio-oriented processes,
this book explores the impact and use of the latest synthetic tools
for the synthesis of...
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All the latest tools needed to plan and perform the synthesis
of complex bioactive molecules
Focusing on organic, organometallic, and bio-oriented processes,
this book explores the impact and use of the latest synthetic tools
for the synthesis of complex biologically active compounds. Readers
will discover step by step how these synthetic tools have provided
new, elegant solutions to many synthetic puzzles. Moreover, they
will discover innovative methods that make it possible to control
the exact connectivity of atoms within a molecule in order to set
precise three-dimensional arrangements.
Modern Tools for the Synthesis of Complex Bioactive
Molecules features sixteen chapters, each one written by one or
more leading experts in organic synthesis from around the world. It
covers a broad range of topics that enable readers to take
advantage of the latest methods for synthesizing complex molecules,
including:
* Modern catalysis, emphasizing key transformations such as C-H
functionalizations, cross-couplings, gold-catalyzed reactions,
metathesis-based syntheses, and asymmetric organocatalysis
* Eco-compatible transformations, including rearrangements and
domino reactions
* Tools for the synthesis of carbohydrates and alkaloids
* New techniques, including the use of fluorous tags and
engineered biosynthesis
The last two chapters explore target- and diversity-oriented
organic synthesis as well as the use of DNA-based asymmetric
catalysis, which are all promising tools for the successful
synthesis of complex bioactive molecules.
Modern Tools for the Synthesis of Complex Bioactive
Molecules is ideal for students and researchers who need to
plan and perform the synthesis of complex molecules as efficiently
as possible. The book's expert advice will help these readers
quickly resolve a broad range of problems that can arise in organic
syntheses.
of complex bioactive molecules
Focusing on organic, organometallic, and bio-oriented processes,
this book explores the impact and use of the latest synthetic tools
for the synthesis of complex biologically active compounds. Readers
will discover step by step how these synthetic tools have provided
new, elegant solutions to many synthetic puzzles. Moreover, they
will discover innovative methods that make it possible to control
the exact connectivity of atoms within a molecule in order to set
precise three-dimensional arrangements.
Modern Tools for the Synthesis of Complex Bioactive
Molecules features sixteen chapters, each one written by one or
more leading experts in organic synthesis from around the world. It
covers a broad range of topics that enable readers to take
advantage of the latest methods for synthesizing complex molecules,
including:
* Modern catalysis, emphasizing key transformations such as C-H
functionalizations, cross-couplings, gold-catalyzed reactions,
metathesis-based syntheses, and asymmetric organocatalysis
* Eco-compatible transformations, including rearrangements and
domino reactions
* Tools for the synthesis of carbohydrates and alkaloids
* New techniques, including the use of fluorous tags and
engineered biosynthesis
The last two chapters explore target- and diversity-oriented
organic synthesis as well as the use of DNA-based asymmetric
catalysis, which are all promising tools for the successful
synthesis of complex bioactive molecules.
Modern Tools for the Synthesis of Complex Bioactive
Molecules is ideal for students and researchers who need to
plan and perform the synthesis of complex molecules as efficiently
as possible. The book's expert advice will help these readers
quickly resolve a broad range of problems that can arise in organic
syntheses.
Inhaltsverzeichnis zu „Modern Tools for the Synthesis of Complex Bioactive Molecules (ePub)“
Foreword Preface Contributors Chapter 1 C-H Functionalization: A New Strategy for the Synthesis of Biologically Active Natural Products Sophie Rousseaux, Benoît Liégault, and Keith Fagnou Chapter 2 The Negishi Cross-Coupling in the Synthesis of Natural Products and Bioactive Molecules Evelina Colacino, Jean Martinez, and Frédéric Lamaty Chapter 3 Metal-Catalyzed C-Heteroatom Cross-Coupling Reactions Renata Marcia de Figueiredo, Jean-Marc Campagne, and Damien Prim Chapter 4 Golden Opportunities in the Synthesis of Natural Products and Biologically Active Compounds Fabien Gagosz Chapter 5 Metathesis-Based Synthesis of Complex Bioactives Jean-Alexandre Richard, Sin Yee Ng, and David Y.-K. Chen Chapter 6 Enantioselective Organocatalysis: A Powerful Tool for the Synthesis of Bioactive Molecules Mitsuru Shoji and Yujiro Hayashi Chapter 7 Asymmetric Phase-Transfer Catalysis Seiji Shirakawa, Shin A. Moteki, and Keiji Maruoka Chapter 8 Rearrangements in Natural Product Synthesis José Marco-Contelles and Elena Soriano Chapter 9 Domino Reactions in the Enantioselective Synthesis of Bioactive Natural Products Lutz F. Tietze, Scott G. Stewart, and M. Alexander Düfert Chapter 10 Fluorous Linker-Facilitated Synthesis of Biologically Interesting Molecules Wei Zhang Chapter 11 The Evolution of Immobilized Reagents and their Application in Flow Chemistry for the Synthesis of Natural Products and Pharmaceutical Compounds Rebecca M. Myers, Kimberley A. Roper, Ian R. Baxendale, and Steven V. Ley Chapter 12 Synthetic Approaches to Bioactive Carbohydrates Xavier Guinchard, Sébastien Picard, and David Crich Chapter 13 Ammonium Ylides as Building Blocks for Alkaloid Synthesis Scott Bur and Albert Padwa Chapter 14 Precursor-Directed Biosynthesis of Polyketide and Non-Ribosomal Peptide Natural Products Colin J. B. Harvey and Chaitan Khosla Chapter 15 Target-Oriented and Diversity-Oriented Organic Synthesis Raphaël Rodriguez Chapter 16 DNA as a Tool for Molecular Discovery Michael Smietana,
... mehr
Jean-Jacques Vasseur, Janine Cossy, and Stellios Arseniyadis Index
... weniger
Autoren-Porträt
JANINE COSSY graduated from the University of Reimsworking under the supervision of Prof. Jean-Pierre Pète. After
a postdoctoral stay with Prof. Barry Trost (1980-1982) at the
University of Wisconsin, she returned to Reims where she became
Director of Research of the CNRS in 1990. The same year, she moved
to Paris to become Professor of Organic Chemistry at the Ecole
Supérieure de Physique et de Chimie Industrielles de la Ville
de Paris (ESPCI ParisTech). She has published over 380 articles and
filed thirteen patents in the field of synthetic organic chemistry
and natural product synthesis. She is Associate Editor at
Organic Letters since 2005.
STELLIOS ARSENIYADIS was born in Greece in 1975. He
studied chemistry at the Université Paris XI and received his
PhD in 2002 from the Université Louis Pasteur (Strasbourg,
France) working under the guidance of Dr. Charles Mioskowski. In
2001, he joined Rhodia ChiRex (Boston, USA) for an eighteen-month
internship in collaboration with Prof. Stephen L. Buchwald (MIT,
USA). He then spent a year as a postdoctoral fellow at Imperial
College London (UK) working under the supervision of Prof. Alan C.
Spivey, after which he joined Prof. K. C. Nicolaou's group at The
Scripps Research Institute (La Jolla, USA) for an additional
postdoc. In 2005, he was appointed by the CNRS as Chargé de
Recherche in Prof. Janine Cossy's group. His research interests
include the development of new synthetic tools and their
application to the total synthesis of complex natural products.
Bibliographische Angaben
- 2012, 1. Auflage, 596 Seiten, Englisch
- Herausgegeben: Janine Cossy, Stellios Arseniyadis
- Verlag: John Wiley & Sons
- ISBN-10: 1118342879
- ISBN-13: 9781118342879
- Erscheinungsdatum: 04.09.2012
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