Mammalian Toxicology (PDF)

Mammalian Toxicology surveys chemical agents and examines
how such chemicals impact on human health, emphasizing the
importance in minimizing environmental exposure to chemical and
physical hazards in our homes, communities and workplaces through
such media as contaminated water, soil and air.

Starting with the basic principles on a wide range of toxic
agents, this textbook describes how they enter the body, their
mechanisms of action once inside, and strategies for diagnosis,
prevention and treatment.

Topics covered include:

* General principles of toxicology: pharmacological and
toxicological principles underpinning the study of
toxicology, risk assessments and mechanisms of cell death

* Disposition: routes of chemical exposures, entry into
the body and various tissues, storage, metabolic biotransformation
and elimination, with examples from various toxicants.

* Toxic agents: the occurrences, disposition in the body,
health effects, toxic mechanisms, antidotes and treatments of a
range of agents including pesticides, metals, solvents, gases,
nanomaterials, food components and additives, pharmaceuticals,
drugs of abuse, natural toxins, endocrine disruptors, radiation,
and warfare weapons.

* Toxic effects: including neurotoxicity, developmental
toxicity, immunotoxicity, teratogenecity, male and female
reproductive toxicity, mutagenecity, carcinogenicity,
pulmonary toxicity, cardiovascular toxicity, hepatotoxicity,
gastrointestinal toxicity and cardiovascular toxicity

* Toxicology and society: epidemiological studies of
chemical-induced diseases in human populations, and a vision for
toxicology in the 21st century.

Mammalian Toxicology is an essential primer for students
of toxicology, biochemistry, biology, medicine and chemistry. It is
also appropriate for professional toxicologists in research or
regulatory affairs, and anyone who needs to understand the adverse
effects of toxic agents on the human body.