Forward-Time Population Genetics Simulations (ePub)

The only book available in the area of forward-time population
genetics simulations--applicable to both biomedical and
evolutionary studies

The rapid increase of the power of personal computers has led to
the use of serious forward-time simulation programs in genetic
studies. Forward-Time Population Genetics Simulations
presents both new and commonly used methods, and introduces
simuPOP, a powerful and flexible new program that can be used to
simulate arbitrary evolutionary processes with unique features like
customized chromosome types, arbitrary nonrandom mating schemes,
virtual subpopulations, information fields, and Python
operators.

The book begins with an overview of important concepts and
models, then goes on to show how simuPOP can simulate a number of
standard population genetics models--with the goal of
demonstrating the impact of genetic factors such as mutation,
selection, and recombination on standard Wright-Fisher models. The
rest of the book is devoted to applications of forward-time
simulations in various research topics.

Forward-Time Population Genetics Simulations
includes:

* An overview of currently available forward-time simulation
methods, their advantages, and shortcomings

* An overview and evaluation of currently available software

* A simuPOP tutorial

* Applications in population genetics

* Applications in genetic epidemiology, statistical genetics, and
mapping complex human diseases

The only book of its kind in the field today, Forward-Time
Population Genetics Simulations will appeal to researchers and
students of population and statistical genetics.