Enzybiotics (PDF)

Presents the latest research and applications for a new,
promising approach to fighting infectious diseases

Enzybiotics is a promising way of fighting bacterial or fungal
infectious diseases by using viruses or viral-derived lysins.
Drawing from the fields of medicinal chemistry, microbiology,
genetics, and biochemistry, this book presents the state of the
science in enzybiotics research, fully exploring its emerging
therapeutic applications.

The book begins with four chapters that review the potential
applications, possible advantages, and phylogeny of enzybiotics.
Next, the book explores:

* A new approach to controlling infections using Gram-negative
bacteria

* Bacteriophage holins and their membrane-disrupting activity

* Anti-staphylococcal lytic enzymes

* Membrane-targeted enzybiotics

* Design of phage cocktails for therapy from a host-range point of
view

* Novel methods to identify new enzybiotics

* Genetically modified phages that deliver suicidal genes to
target bacteria

The authors, all active enzybiotics researchers, offer a variety
of perspectives, the benefit of their own hands-on investigations,
as well as a thorough review and analysis of the current
literature.

As more and more bacteria become resistant to antibiotics, the
development of new disease-fighting agents has become essential.
This book demonstrates the full potential of the emerging field of
enzybiotics to control infectious diseases. Moreover, it will serve
as a springboard for new research and the development of new
therapeutics.