Engineering Complex Phenotypes in Industrial Strains (PDF)
(Sprache: Englisch)
This book highlights current trends and developments in the area of
engineering strains. The book details the current and future tools
used in the production of bulk chemicals and biofuels from
renewable biomass using green technologies. Complex...
engineering strains. The book details the current and future tools
used in the production of bulk chemicals and biofuels from
renewable biomass using green technologies. Complex...
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This book highlights current trends and developments in the area of
engineering strains. The book details the current and future tools
used in the production of bulk chemicals and biofuels from
renewable biomass using green technologies. Complex phenotypes are
traits in a microbe that requires multiple genetic changes to be
modulated simultaneously in the microorganism's DNA. Knowing
what those genetic changes are for a given trait and how to make
those changes in the most efficient way forms the motivation behind
writing this book. This book explains the newer tools to develop
and enable engineered strains at time scales much faster that the
natural evolution process so that we can increase a cells'
production of a certain substance, increase process productivity,
and extend metabolic capability. This book provides a one stop
platform of reference for practicing researchers in the field of
industrial biotechnology. This book also explains that the
commercial success of a process that uses microbial catalysts over
platforms that use chemical catalysts and fossil fuels depends on
the time it takes to engineer these microbes to perform the desired
reaction under harsh manufacturing conditions and at rates that
meets the criteria for economic feasibility.
engineering strains. The book details the current and future tools
used in the production of bulk chemicals and biofuels from
renewable biomass using green technologies. Complex phenotypes are
traits in a microbe that requires multiple genetic changes to be
modulated simultaneously in the microorganism's DNA. Knowing
what those genetic changes are for a given trait and how to make
those changes in the most efficient way forms the motivation behind
writing this book. This book explains the newer tools to develop
and enable engineered strains at time scales much faster that the
natural evolution process so that we can increase a cells'
production of a certain substance, increase process productivity,
and extend metabolic capability. This book provides a one stop
platform of reference for practicing researchers in the field of
industrial biotechnology. This book also explains that the
commercial success of a process that uses microbial catalysts over
platforms that use chemical catalysts and fossil fuels depends on
the time it takes to engineer these microbes to perform the desired
reaction under harsh manufacturing conditions and at rates that
meets the criteria for economic feasibility.
Inhaltsverzeichnis zu „Engineering Complex Phenotypes in Industrial Strains (PDF)“
Foreword John Pierce PREFACE Ranjan Patnaik CHAPTER 1 Classical Strain Engineering Nathan Crook and Hal Alper CHAPTER 2 Tracer-based Analysis of Metabolic Flux Networks Michael Dauner CHAPTER 3 Integration of 'Omics' Data with Genome-scale Metabolic Models Stephen Van Dien, Priti Pharkya, and Robin Osterhout CHAPTER 4 Strain Improvement via Evolutionary Engineering Byoungjin Kim, Jing Du, and Huimin Zhao CHAPTER 5 Rapid Fermentation Process Development and Optimization Jun Sun and Lawrence Chew CHAPTER 6 The Clavulanic Acid Strain Improvement Program at DSM Anti-Infectives Bert Koekman and Marcus Hans CHAPTER 7 Metabolic Engineering of recombinant E. coli for the Production of 3-Hydroxypropionate Tanya Warnecke Lipscomb, Matthew L. Lipscomb, and Michael D. Lynch CHAPTER 8 Complex System Engineering: A Case Study for an Unsequenced Microalga Michael Guarnieri,Yat-Chen Chou, Bryon S. Donohoe, Eric Knoshaug, Lieve Laurens and Phillip T. Pienkos CHAPTER 9 Meiotic Recombination-based genome shuffling of Saccharomyces cerevisiae and Schefferomyces stiptis for increased inhibitor tolerance to lignocellulosic substrate toxicity Dominic Pinel and Vincent J. J. Martin
Autoren-Porträt von Ranjan Patnaik
RANJAN PATNAIK, PhD, is a chemical engineer by professionwith 17 years of practical experience in the field of industrial
biotechnology that includes small biotech start-ups and large
enterprises. His research interests are in the field of metabolic
engineering, fermentation optimization, process integration and
R&D technology management. He currently heads the biofuels
research group at DuPont Knowledge Center (DKC), Hyderabad, India.
Prior to his current role, he had a variety of responsibilities
within the biochemical sciences & engineering division of
CR&D, E. I. du Pont de Nemours and Company, Wilmington, DE,
USA.
Bibliographische Angaben
- Autor: Ranjan Patnaik
- 2012, 1. Auflage, 280 Seiten, Englisch
- Verlag: John Wiley & Sons
- ISBN-10: 1118433009
- ISBN-13: 9781118433003
- Erscheinungsdatum: 19.09.2012
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