Drug Metabolism in Drug Design and Development (PDF)

Preface. Contributors. Part I: Basic Concepts of Drug Metabolism. 1. Overview: Drug Metabolism in the Modern Pharmaceutical Industry (Scott J. Grossman) 2. Oxidative, Reductive, and Hydrolytic Metabolism of Drugs (F. Peter Guengerich) 3. Conjugative Metabolism of Drugs (Rory Remmel, Swati Nagar and Upendra Argikar) 4. Enzyme Kinetics (Timothy S. Tracy) 5. Metabolism-Mediated Drug-Drug Interactions (Hongjian Zhang, Michael W. Sinz, and A. David Rodrigues) 6. Drug Transporters in Drug Disposition, Drug Interactions, and Drug Resistance (Cindy Q. Xia, Johnny J. Yang, and Suresh K. balani) 7. Regulatory Considerations of Drug Metabolism and Drug Interaction Studies (Xiaoxiong Wei and Mingshe Zhu) Part II: Role of Drug Metabolism in the Pharmaceutical Industry. 8. Drug Metabolism Research as an Integral Part of the Drug Discovery Process (W. Griffith Humphreys) 9. Role of Drug Metabosim in Drug Development (Ramaswamy Iyer and Donglu Zhang) Part III: Analytical techniques in Drug Metabolism. 10. Applications of Liquid Radiochromatography Techniques in Drug Metabolism Studies (Mingshe Zhu, Weiping Zhao, and W. Griffith Humphreys) 11. Application of Liquid Chromatogrpahy/Mass Spectrometry for Metabolite Identification (Shuguang Ma and Swapan K. Chowdhury) 12. Introductin to NMR and Its Application in Metabolite Structure Determination (Xiaohua Huang, Robert Powers, Adrienne Tymiak, Robert Espina, and Vikram Roongta) Part IV: Common Experimental Approaches and Protocols. 13. Determination of Metabolic Rats and Enzyme Kinetics (Zhi-Yi Zhang and Laurence S. Kaminsky) 14. Protocols for Assessment of In vitro and In vivo Bioactivation Potential of Drug Candidates (Zhoupeng Zhang and Jinping Gan) 15. Reaction Phenotyping (Susan Hurst, J. Andrew Williams, and Steven Hansel) 16. Analysis of In vitro Cytochrome P450 Inhibition in Drug Discovery and Development (Magang Shou and Renke Dai) 17. Testing Drug Candidates for CYP3A4 Induction (Gang Luo, Liang-Shang Gan, and Thomas M.

Donglu Zhang, PhD, is a senior scientist in the
Biotransformation Depart-ment at Bristol-Myers Squibb. His research
interests include metabolite characterization, drug metabolism
enzymology, LC/MS methodologies, and microbial
biotransformation.

MINGSHE ZHU, PhD, is a drug metabolism scientist with more than
ten years of experience in drug discovery and development. His
research interests include metabolic activation, LC/MS technology,
and regulatory drug metabolism.

W. Griffith Humphreys, PhD, is the Director of the
Biotransformation Department at Bristol-Myers Squibb. His research
interests include optimizationof ADME properties, metabolic
activation, and new methodologies for metabolite
characterization.

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