Drug Discovery and Development, Volume 2 (PDF)

From first principles to real-world applications-here is the
first comprehensive guide to drug discovery and development

Modern drug discovery and development require the collaborative
efforts of specialists in a broadarray of scientific, technical,
and business disciplines-from biochemistry to molecular biology,
organic chemistry to medicinal chemistry, pharmacology to
marketing. Yet surprisingly, until now, there were no authoritative
references offering a complete, fully integrated picture of the
process.

The only comprehensive guide of its kind, this groundbreaking
two-volume resource provides an overview of the entire sequence of
operations involved in drug discovery and develop-?ment-from
initial conceptualization to commercialization to clinicians and
medical practitioners.

Volume 1: Drug Discovery describes all the steps in the
discovery process, including conceptualizing a drug, creating a
library of candidates for testing, screening candidates for in
vitro and in vivo activity, conducting and analyzing the results of
clinical trials, and modifying a drug as necessary.

Volume 2: Drug Development delves into the nitty-gritty
details of optimizing the synthetic route, drug manufacturing,
outsourcing, and marketing-including drug coloring and delivery
methods.

Featuring contributions from a world-class team of experts,
Drug Discovery and Development:

* Features fascinating case studies, including the discovery and
development of erythromycin analogs, Tagamet, and Ultiva
(remifentanil)

* Discusses the discovery of medications for bacterial
infections, Parkinson's disease, psoriasis, peptic ulcers, atopic
dermatitis, asthma, and cancer

* Includes chapters on combinatorial chemistry, molecular
biology-based drug discovery, genomics, and chemogenomics

Drug Discovery and Development is an indispensable
working resource for industrial chemists, biologists, biochemists,
and executives who work in the pharmaceutical industry.