Drug Design and Discovery in Alzheimer's Disease (ePub)
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Drug Design and Discovery in Alzheimer's Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ss-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery.
- Edited and written by leading experts in Alzheimer's disease (AD) and other neurodegenerative disease drug development
- Describes existing drugs for AD and current molecular understanding of the condition
- Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets
Muhammad Choudhary, PhD, is a Professor of the International Center for Chemical and Biological Sciences, (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan. He is a member of the Royal Society of Chemistry, London; American Chemical Society; International Union of Pure and Applied Chemistry (IUPAC); American Society of Pharmacology; New York Academy of Sciences; Federation of Asian Chemical Societies (FACS); and he serves on the executive board of the Asian Network of Research on Anti Diabetic Plants (ANRAP). He is a recipient of the National Book Foundation's Prize for Chemistry and the Economic Cooperation Organization (ECO) Award in Education, 2006, given by the President of Azerbaijan. He has published 24 books, more than 570 papers, and 20 patents.
- 2015, 784 Seiten, Englisch
- Herausgegeben: Atta-Ur Rahman, Muhammad Iqbal Choudhary
- Verlag: Elsevier Science & Techn.
- ISBN-10: 0128039604
- ISBN-13: 9780128039601
- Erscheinungsdatum: 27.06.2015
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- Dateiformat: ePub
- Grösse: 15 MB
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