Diversity-Oriented Synthesis (PDF)

Discover an enhanced synthetic approach to developing and
screening chemical compound libraries

Diversity-oriented synthesis is a new paradigm for developing
large collections of structurally diverse small molecules as probes
to investigate biological pathways. This book presents the most
effective methods in diversity-oriented synthesis for creating
small molecule collections. It offers tested and proven strategies
for developing diversity-oriented synthetic libraries and screening
methods for identifying ligands. Lastly, it explores some promising
new applications based on diversity-oriented synthesis that have
the potential to dramatically advance studies in drug discovery and
chemical biology.

Diversity-Oriented Synthesis begins with an introductory
chapter that explores the basics, including a discussion of the
relationship between diversity-oriented synthesis and classic
combinatorial chemistry. Divided into four parts, the book:

* Offers key chemical methods for the generation of small
molecules using diversity-oriented principles, including
peptidomimetics and macrocycles

* Expands on the concept of diversity-oriented synthesis by
describing chemical libraries

* Provides modern approaches to screening diversity-oriented
synthetic libraries, including high-throughput and high-content
screening, small molecule microarrays, and smart screening
assays

* Presents the applications of diversity-oriented synthetic
libraries and small molecules in drug discovery and chemical
biology, reporting the results of key studies and forecasting the
role of diversity-oriented synthesis in future biomedical
research

This book has been written and edited by leading international
experts in organic synthesis and its applications. Their
contributions are based on a thorough review of the current
literature as well as their own firsthand experience developing
synthetic methods and applications.

Clearly written and extensively referenced,
Diversity-Oriented Synthesis introduces novices to this
highly promising field of research and serves as a springboard for
experts to advance their own research studies and develop new
applications.