Click Chemistry in Glycoscience (PDF)

Lays the foundation for new methods and applications of
carbohydrate click chemistry

Introduced by K. Barry Sharpless of The Scripps Research
Institute in 2001, click chemistry mimics nature, giving
researchers the tools needed to generate new substances quickly and
reliably by joining small units together. With contributions from
more than thirty pioneering researchers in the field, this text
explores the many promising applications of click chemistry in
glycoscience. Readers will learn both the basic concepts of
carbohydrate click chemistry as well as its many biomedical
applications, including synthetic antigens, analogs of cell-surface
receptors, immobilized enzymes, targeted drug delivery systems, and
multivalent cancer vaccines.

Click Chemistry in Glycoscience examines a broad range of
methodologies and strategies that have emerged from this rapidly
evolving field. Each chapter describes new approaches, ideas,
consequences, and applications resulting from the introduction of
click processes. Divided into four sections, the book covers:

* Click chemistry strategies and decoupling

* Thio-click chemistry of carbohydrates

* Carbohydrate click chemistry for novel synthetic targets

* Carbohydrate click chemistry in biomedical sciences

Thoroughly researched, the book reflects the most recent
findings published in the literature. Diagrams and figures
throughout the book enable readers to more easily grasp complex
concepts and reaction processes. At the end of each chapter,
references lead to the primary literature for further investigation
of individual topics.

The application of click chemistry to carbohydrates has
tremendous implications for research. With this book as their
guide, researchers have a solid foundation from which they can
develop new methods and applications of carbohydrate click
chemistry, including new carbohydrate-based therapeutics.