Acetaldehyde-Related Pathology / Novartis Foundation Symposium (PDF)
Bridging the Trans-Disciplinary Divide
(Sprache: Englisch)
Part of the prestigious Novartis Foundation, this is the first book
to review the pathology associated with acetaldehyde, a known toxic
agent found in cigarette smoke and other pollutants and derived
from ingested alcohol, amongst other sources. In the...
to review the pathology associated with acetaldehyde, a known toxic
agent found in cigarette smoke and other pollutants and derived
from ingested alcohol, amongst other sources. In the...
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Produktinformationen zu „Acetaldehyde-Related Pathology / Novartis Foundation Symposium (PDF)“
Part of the prestigious Novartis Foundation, this is the first book
to review the pathology associated with acetaldehyde, a known toxic
agent found in cigarette smoke and other pollutants and derived
from ingested alcohol, amongst other sources. In the body,
acetaldehyde affects several tissues, particularly the brain and
liver, causing various diseases, including cancer, alcoholic liver
disease and Alzheimer's.
Acetaldehyde-Related Pathology describes the toxic
effects of acetaldehyde at the tissue and cellular levels,
reviewing enzyme biochemistry, transgenic mouse models of alcohol
dehydrogenase mutants, and the cell-signalling pathways implicated
in alcohol-related pathology. It explores the mechanisms of
acetaldehyde-induced damage to tissues, often a first step in
carcinogenesis, including the oral cavity, the human airway, and
the GI tract. The book considers pharmacological strategies and
treatments for reducing oral and intestinal acetaldehyde.
Acetaldehyde-Related Pathology features in-depth,
round-table discussions by an international array of scientists
from major laboratories worldwide involved in studies of
acetaldehyde-related pathology.
This book is essential reading for anyone interested in the
effects of this compound - pathologists, biochemists,
toxicologists, cell and molecular biologists.
to review the pathology associated with acetaldehyde, a known toxic
agent found in cigarette smoke and other pollutants and derived
from ingested alcohol, amongst other sources. In the body,
acetaldehyde affects several tissues, particularly the brain and
liver, causing various diseases, including cancer, alcoholic liver
disease and Alzheimer's.
Acetaldehyde-Related Pathology describes the toxic
effects of acetaldehyde at the tissue and cellular levels,
reviewing enzyme biochemistry, transgenic mouse models of alcohol
dehydrogenase mutants, and the cell-signalling pathways implicated
in alcohol-related pathology. It explores the mechanisms of
acetaldehyde-induced damage to tissues, often a first step in
carcinogenesis, including the oral cavity, the human airway, and
the GI tract. The book considers pharmacological strategies and
treatments for reducing oral and intestinal acetaldehyde.
Acetaldehyde-Related Pathology features in-depth,
round-table discussions by an international array of scientists
from major laboratories worldwide involved in studies of
acetaldehyde-related pathology.
This book is essential reading for anyone interested in the
effects of this compound - pathologists, biochemists,
toxicologists, cell and molecular biologists.
Inhaltsverzeichnis zu „Acetaldehyde-Related Pathology / Novartis Foundation Symposium (PDF)“
Symposium on Acetaldehyde-related pathology: bridging the trans-disciplinary divide, held at the Novartis Foundation, London 5-7th September. Editors: Derek J. Chadwick (Organizer) and Jamie Goode This symposium is based on a proposal made by Victor Preedy, Peter Emery and Mikko Salaspuro Peter Emery Chair's introduction. David W. Crabb and Suthat Liangpunsakul Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes. Discussion. Richard A. Deitrich, Dennis Petersen and Vasilis Vasiliou Removal of acetaldehyde from the body. Discussion. Shih-Jiun Yin and Giia-Sheun Peng Acetaldehyde, polymorphisms and the cardiovascular system. Discussion. Jun Ren Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. Discussion. Mikko Salaspuro Interrelationship between alcohol, smoking, acetaldehyde and cancer. Discussion. Hiroto Matsuse, Chizu Fukushima, Terufumi Shimoda, Sadahiro Asai and Shigeru Kohno Effects of acetaldehyde on human airway constriction and infl ammation. Discussion. Helmut K. Seitz The role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tract. Discussion. Robert Tardif The determination of acetaldehyde in exhaled breath. Discussion. Mostofa Jamal, Kiyoshi Ameno, Mitsuru Kumihashi, Weihuan Wang, Ikuo Uekita and Iwao Ijiri Ethanol and acetaldehyde: in vivo quantitation and effects on cholinergic function in rat brain. Discussion. Ville Salaspuro Pharmacological treatments and strategies for reducing oral and intestinal acetaldehyde. Discussion. Victor R. Preedy, David W. Crabb, Jaume Farrés and Peter W. Emery Alcoholic myopathy and acetaldehyde. Discussion. Onni Niemelä Acetaldehyde adducts in circulation. Discussion. General discussion. M. Apte, J. McCarroll, R. Pirola and J. Wilson Pancreatic MAP kinase pathways and acetaldehyde. Discussion. Shivendra D. Shukla, Youn Ju Lee, Pil-hoon Park and Annayya R.
... mehr
Aroor Acetaldehyde alters MAP kinase signalling and epigenetic histone modifi cations in hepatocytes. Discussion. Paul J. Thornalley Endogenous alpha-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage. Discussion. C. J. Peter Eriksson Measurement of acetaldehyde: what levels occur naturally and in response to alcohol? Discussion. Final discussion. Contributors Index. Subject Index.
... weniger
Autoren-Porträt
The Novartis Foundation is an international scientific andeducational charity which promotes the study and general knowledge
of science and in particular encourages international co-operation
in scientific research.
Chairman: Peter Emery
Bibliographische Angaben
- 2007, 8. Auflage, 286 Seiten, Englisch
- Herausgegeben: Derek J. Chadwick, Jamie A. Goode
- Verlag: John Wiley & Sons
- ISBN-10: 0470511834
- ISBN-13: 9780470511831
- Erscheinungsdatum: 30.04.2007
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