The Extraordinary Biology of the Naked Mole-Rat

Dedication.- About the editors.- Preface (Jarvis JUM).- Chapter 1. Social evolution in African mole-rats - a comparative overview (Faulkes CG & Bennett NC).- Chapter 2. Social behavior in naked mole-rats: individual differences in phenotype and proximate mechanisms of mammalian eusociality (Holmes MM & Goldman BD).- Chapter 3. Neuropeptidergic and neuroendocrine systems underlying eusociality and the concomitant social regulation of reproduction in naked mole-rats: a comparative approach (Coen CW, Bennett N, Holmes MM, & Faulkes CG).- Chapter 4. Adult neural plasticity in naked mole-rats: implications of fossoriality, longevity and sociality on the brain's capacity for change (Mooney SJ, Forger NG, & Holmes MM).- Chapter 5. Sensory Systems of the African Naked Mole-Rat (Vice EN, Lagestee S, Browe BM, Deb D, Smith ESJ, Park TJ).- Chapter 6. Hearing and vocalizations in the naked mole-rat (Barker AJ, Koch, U, Lewin GR, Pyott, SJ).- Chapter 7. The somatosensory world of the African naked mole-rat (Lewin GR, Smith ESJ, Reznick J, Debus K, Barker A, and Park TJ).- Chapter 8. The idiosyncratic physiological traits of the naked mole-rat; a resilient animal model of aging, longevity, and healthspan (Buffenstein R and Craft W).- Chapter 9. African Naked Mole-Rats Demonstrate Extreme Tolerance to Hypoxia and Hypercapnia (Park TJ, Smith ESJ, Reznick J, Bennett NC, Applegate DT, Larson J, Lewin GR).- Chapter 10. A sweet story of metabolic innovation in the naked mole-rat (Reznick J, Park TJ, and Lewin GR).- Chapter 11. Insights into the molecular basis of genome stability and pristine proteostasis in naked mole-rats (Narayan V, McMahon M, O'Brien J, McAllister F and Buffenstein R).- Chapter 12. The Unusual Immune System of the Naked Mole-Rat (Lin TD and Buffenstein R).- Chapter 13.- Induced Pluripotent Stem Cells from Cancer-Resistant Naked Mole-rats (Miura. K, Oiwa Y, and Kawamura Y).- Chapter 14. Naked mole-rats: resistant to developing cancer or good at

Dr. Rochelle (Shelley) Buffenstein is a Senior Principal Investigator at Calico Life Sciences LLC, a company dedicated to harnessing advanced technologies to understand the basic biology of aging. She is also an adjunct professor in the Department of Pharmacology at the University of Texas Health Science Center at San Antonio. Shelley has published more than 180 publications, and has been recognized with several awards, including a Breakthroughs in Gerontology award from the Glenn Foundation, an Ellison Medical Foundation Senior scholar award, the ADPS Longevity Award and the American Aging Association Denham Harman Lifetime Achievement award. Shelley started off her career as an ecophysiologist studying a diverse suite of species that inhabit extremely challenging environments, undertaking her PhD under the mentorship of Jenny Jarvis on the ecophysiology of desert rodents. While a student at the University of Cape Town, she accompanied Jenny Jarvis on various field trips to Kenya, Namibia and within South Africa to undertake field work on mole-rats and other rodents. A key focus of her research over the last 30 years has been the physiology, endocrinology and aging biology of the exceptionally long-lived (~35 years) naked mole-rat and the molecular mechanisms these mouse-size rodents employ to maintain good health, reproductive fitness and cognition well into their third decade. Working with a species that hasn't read the textbook of how to behave like a mammal has been an incredibly rewarding experience, forging terrific friendships through collaboration and intriguing scientific challenges.
Thomas Park is a professor of Biological Sciences and Neuroscience at the University of Illinois at Chicago. His graduate training was in behavioral assessments of sound perception in birds and gerbils. His post-doctoral training was in electrophysiology of auditory brain regions in awake bats. After taking a position at the University of Illinois at Chicago, he obtained a