The Book of GENESIS

'I Neurobiological Tutorials with GENESIS.- 1 Introduction.- 1.1 Computational Neuroscience.- 1.2 Using This Book.- 2 Compartmental Modeling.- 2.1 Modeling Neurons.- 2.1.1 Detailed Compartmental Models.- 2.1.2 Equivalent Cylinder Models.- 2.1.3 Single and Few Compartment Models.- 2.2 Equivalent Circuit of a Single Compartment.- 2.3 Axonal Connections, Synapses and Networks.- 2.4 Simulation Accuracy.- 2.4.1 Choice of Numerical Integration Technique.- 2.4.2 Integration Time Step.- 2.4.3 Accuracy of GENESIS.- 3 Neural Modeling with GENESIS.- 3.1 What Is GENESIS?.- 3.1.1 Why Use a General Simulator?.- 3.1.2 GENESIS Design Features.- 3.1.3 GENESIS Development.- 3.2 Introduction to the Tutorials.- 3.3 Introduction to the GENESIS Graphical Interface.- 3.3.1 Starting the Simulation.- 3.3.2 The Control Panel.- 3.3.3 Using Help Menus.- 3.3.4 Displaying the Simulation Results.- 4 The Hodgkin-Huxley Model.- 4.1 Introduction.- 4.2 Historical Background.- 4.3 The Mathematical Model.- 4.3.1 Electrical Equivalent Circuit.- 4.3.2 HH Conventions.- 4.3.3 The Ionic Current.- 4.4 Voltage Clamp Experiments.- 4.4.1 Characterizing the K Conductance.- 4.5 GENESIS: Voltage Clamp Experiments.- 4.6 Parameterizing the Rate Constants.- 4.7 Inactivation of the Na Conductance.- 4.8 Current Injection Experiments.- 4.9 Exercises.- 5 Cable and Compartmental Models of Dendritic Trees.- 5.1 Introduction.- 5.2 Background.- 5.2.1 Dendritic Trees: Anatomy, Physiology and Synaptology.- 5.2.2 Summary.- 5.3 The One-Dimensional Cable Equation.- 5.3.1 Basic Concepts and Assumptions.- 5.3.2 The Cable Equation.- 5.4 Solution of the Cable Equation for Several Cases.- 5.4.1 Steady-State Voltage Attenuation with Distance.- 5.4.2 Voltage Decay with Time.- 5.4.3 Functional Significance of ? and ?m.- 5.4.4 The Input Resistance Rin and "Trees Equivalent to a Cylinder".- 5.4.5 Summary of Main Results from the Cable Equation.- 5.5 Compartmental Modeling Approach.- 5.6 Compartmental Modeling Experiments.- 5.7 Main

The Book of GENESIS , in its new, 2nd edition, remains an invaluable modeling and simulation resource and tool for a wide audience of neuroscience students, researchers and professionals. The addition of new chapter materials in the book, and the availability of a cross-platform CD-ROM containing all of the source code to the latest version of the GENESIS software, version 2.1, as well as many other important new components to the GENESIS system, give this new edition significant added-value for current and prospective users.