The Beginnings of Cancer in the Cell

Preface.- (The History of Cancer).- References.- 1 Do We Carry the Cause of Cancer in Our Genes?.- 1.1 Viral Cancer Causing Genes.- 1.2 Oncogenes in Plants and Animals.- 1.3 Human Cancer Causing Genes.- References.- 2 Activation of Cancer-Causing Genes (Biochemical Discussion).- 2.1 Activation of Oncogenes Through Mutations.- 2.2 Overactivation of Some Normal Genes.- 2.2.1 Overactivation by DNA Segments of Viral Origin.- 2.2.2 Translocation of Genes.- 2.3 Other Biochemical Possibilities of Oncogene Activation.- 2.3.1 Amplification.- 2.3.2 Antioncogene Deactivation.- 2.3.3 DNA Transposition.- References.- 3 The Role of External Factors in the Start of the Cancerous Change in a Cell.- 3.1 Different Cancer Initiating Chemical Compounds (Carcinogens) and Their Most Important Reactions in the Cell.- 3.2 The Role of Electromagnetic and Particle Radiation.- 3.3 Other Factors Involved in Cancer Initiation, e.g. Role of Trace Elements in the Cell, Heat or Continous Local Pressure.- 3.4 The Role of a Second Group of Chemicals: Cancer Promoters.- References.- 4 A Brief Summary of the Structure of DNA and Proteins and their Biological Role.- 4.1 The Chemical and Geometrical Structure of DNA and Proteins.- 4.2 The Biological Role of DNA and Proteins.- References.- 5 Mechanism of Oncogene Activation or Antioncogene Inactivation by External Factors.- 5.1 Carcinogens and Radiation Affect DNA Not Only Locally.- 5.2 Local Effects of Carcinogens and Their Effect on Oncogene Activation (Point Mutations).- 5.3 Different Long Range Physical Effects of Carcinogens.- 5.3.1 Energy Bands in DNA and Proteins and Their Change Through Carcinogen Binding.- 5.3.2 Different Long-range Effects of Carcinogens Bound to DNA or Proteins.- 5.3.3 Connections Between the Different Long Range Physical Effects of Carcinogens and the Activation of Oncogenes.- 5.4 The Effects of Radiation on DNA.- 5.4.1 Direct Hit UV Radiation.- 5.4.2 Particle Radiation.- 5.4.3 Qualitative Theory of Double Strand Breaks and