Technical Aspects of Toxicological Immunohistochemistry
System Specific Biomarkers
(Sprache: Englisch)
This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues. Eleven comprehensive chapters provide pathologists and researchers in various...
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Klappentext zu „Technical Aspects of Toxicological Immunohistochemistry “
This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues. Eleven comprehensive chapters provide pathologists and researchers in various sub-disciplines of toxicology with a comprehensive review of the methods and approaches for immunohistochemical staining in various target tissues. It explores the tissue-antigen and antibody-specific problems that may be encountered during the staining procedures and provide potential avenues for resolving various methodological issues. Special attention is paid to the latest enhancement procedures for antigen retrieval and visualization as well as image analysis and antigen quantification. Written by leading researchers in toxicology and pathology, this book is a significant resource for toxicologists and pathologists working with rodents, monkeys and aquatic animal tissues.
Inhaltsverzeichnis zu „Technical Aspects of Toxicological Immunohistochemistry “
1.Immunohistochemistry - Overview, Its Potential and Challenges.- 2.Tissue Micro Array (TMA) Technology and its Potential Applications in Toxicology and Toxicological Immunohistochemistry.- 3.Importance of Fluorescent In Situ Hybridization (FISH) in Rodent Tumors.- 4.Quantitation of Immunohistochemistry by Image Analysis Technique.- 5.Immunohistochemistry in the Study of Cancer Biomarkers for Oncology Drug Development.- 6.Male Reproductive Toxicology and the Role of Immunohistochemistry.- 7. Immunohistochemistry and Female Reproductive Toxicology: The Ovary and Mammary Gland.- 8.Immunohistochemistry on Rodent Circulatory System: Its Possible Use in Investigating Hypertension.- 9.Role of Lymphoid/Mucosa-Associated Lymphoid Tissue Markers in Toxicological Immunohistochemistry. 10.Bone Markers and Immunohistochemistry Changes in Toxic Environments.- 11. Biomarkers of Skeletal Muscle Injury in the Rat.Autoren-Porträt
Syed A Aziz, Ph.D. Regulatory Toxicology Research Division, Bureau of Chemical Safety
Food Directorate, Health Products and Food Branch
Health Canada
Adjunct professor, Faculty of Medicine Dept. of Pathology
University of Ottawa
Rekha Mehta, Ph.D.
Regulatory Toxicology Research Division, Bureau of Chemical Safety
Food Directorate, Health Products and Food Branch
Health Canada.
Bibliographische Angaben
- 2019, Softcover reprint of the original 1st ed. 2016, XI, 231 Seiten, 3 farbige Abbildungen, Masse: 15,5 x 23,3 cm, Kartoniert (TB), Englisch
- Herausgegeben: Syed A. Aziz, Rekha Mehta
- Verlag: Springer, Berlin
- ISBN-10: 1493979655
- ISBN-13: 9781493979653
Sprache:
Englisch
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