Subunit Vaccine Delivery

1 Immunological Background.- 2 Classification of Vaccines.- 3 Aluminum Adjuvants - Basic Concepts and Progress in Understanding.- 4 Emulsions as Vaccine Adjuvants.- 5 The application of liposomes as vaccine adjuvants.- 6 Developing Bilayer-based Delivery Systems for Oral Delivery of Subunit Vaccines.- 7 Cubosomes - Structure, Preparation and Use as an Antigen Delivery System.- 8 ISCOMs as a Vaccine Delivery System.- 9 Virus-like Particles, a Versatile Subunit Vaccine Platform.- 10 Polymeric Particulates for Subunit Vaccine Delivery.- 11 Gels as Vaccine Delivery Systems.- 12 Implants as Sustained Release Delivery Devices for Vaccine Antigens.- 13 Dendritic Cell-based Vaccines.- 14 Parenteral Vaccine Administration - Tried and True.- 15 Nasal Administration of Vaccines.- 16 Pulmonary Administration of Subunit Vaccines.- 17 Vaginal Delivery of Subunit Vaccines.- 18 Transcutaneous Administration.- 19 Pharmaceutical Analysis and Quality Control of Vaccines.- 20 The Physical Analysis of Vaccines.- 21 Characterizing the Association between Antigens and Adjuvants.

Associate Professor Camilla Foged is the head of the Vaccine Design and Delivery Group in Section of Biologics, Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark. She has an MSc in Biochemistry from University of Copenhagen. Camilla attained her PhD from The Danish University of Pharmaceutical Sciences. CamillaŽs main research interest is advanced drug delivery aiming at designing new vaccine and nucleic acid delivery systems to improve therapy. The group efficiently has addressed drug delivery challenges with cutting edge technologies, which has enabled high impact publications and innovative solutions in drug delivery. Our research goal is to improve disease prevention and treatment by designing nanoparticulate vaccine and nucleic acid formulations through an in depth knowledge of how the physicochemical properties of the particles affect their interaction with the environment, e.g. in formulation, in vitro and in vivo. We are interested in lipid- and polymer-based nanoparticulate delivery systems using various approaches for targeting and membrane destabilization.

Professor Thomas Rades is the Research Chair in Pharmaceutical Design and Drug Delivery in the Department of Pharmacy, University of Copenhagen. He has developed an international reputation for his research on solid dosage forms as well as in vaccine delivery using nanoparticulate systems. Research in both areas aims to improve drug therapy through appropriate formulation and physicochemical characterisation of medicines and vaccines. It combines physical, chemical, and biological sciences and technology to optimally formulate drugs and vaccines for human and veterinary uses. Professor Rades has published more than 270 papers in international peer review journals.

Professor Yvonne Perrie is the Head of Pharmacy and Chair in Drug Delivery within Aston Pharmacy School, Aston University, Birmingham, UK. She has a BSc (First-Class Hons) in Pharmacy from Strathclyde University.