Studies on Psychiatric Disorders
(Sprache: Englisch)
This authoritative volume reviews clinical, pathophysiological and therapeutic aspects of oxidative and nitrosative stress in different psychiatric disorders such as schizophrenia, bipolar disorder, autism, and attention deficit hyperactivity disorder...
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This authoritative volume reviews clinical, pathophysiological and therapeutic aspects of oxidative and nitrosative stress in different psychiatric disorders such as schizophrenia, bipolar disorder, autism, and attention deficit hyperactivity disorder (ADHD). Twenty-nine comprehensive chapters are divided into three distinct sections: clinical aspects, pathophysiological aspects, and therapeutic aspects. Together, these chapters present the environmental, genetic and neurodevelopmental factors in the generation of oxidative stress in psychiatric disorders, with particular emphasis on the biochemical changes associated with oxidative stress in dopaminergic and glutamate neurotransmission as well as mitochondrial dysfunction in the brain and peripheral cells. Through an investigation of glutamic acid decarboxylase (GAD) abnormalities in schizophrenia, the book provides a coherent framework to account for the impact of oxidative stress on pathological phenomena ranging from cellular to cognitive and clinical aspects. It describes biomarkers of oxidative damage, the role of oxidative stress in numerous abnormalities of biochemical pathways in the pathophysiology of schizophrenia, the development of new investigative techniques, specially neuroimaging, and studies of apoptotic pathways that seem to prove neurodegenerative and neurodevelopmental theories.Written by leading researchers in their fields, Studies on Psychiatric Disorders explores therapeutic approaches with aspects of various antioxidants, cryostimulation, and hyperbaric oxygen treatment in oxidative stress in neuropsychiatric diseases. The volume also discusses the role of antipsychotics in the treatment of schizophrenia on nitric oxide generation and biomarkers of oxidative stress together with the clinical symptomatology. Overall, it proposes that novel therapeutic strategies such as supplementation with antioxidants-in particular polyphenols, -3 fatty acids orcombination of both-could
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be effective for long-term treatment of some neuropsychiatric disorders.
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Inhaltsverzeichnis zu „Studies on Psychiatric Disorders “
1. Oxidative nitrative and chlorinative stress: biomarkersPart 1. Clinical aspects
2. Oxidative stress in schizophrenia
3. Oxidative stress in bipolar disorders
4. Contribution of oxidative stress to the pathophysiology of autism spectrum disorders: Impact of genetic and environmental factors
5. Oxidative stress and anxiety disorder
6. The relationship between oxidative stress and obsessive- compulsive disorder
7. A relationship between oxidative status and attention deficit hyperactivity disorder
8. The role of oxidative stress in neurodegenerative diseases
Part 2. Pathophysiological aspects
9. Magnetic resonance spectroscopy studies in Bipolar Disorder patients: Focus on the potential role of oxidative stress
10. The impact of oxidative stress on dopaminergic neurotransmission
11. The reciprocal effects of oxidative stress and glutamate neurotransmission
12. Mitochondrial dysfunction in psychiatric disorders
13. The kynurenine pathway at the interface between neuroinflammation, oxidative stress and neurochemical disturbances: Emphasis in schizophrenia
14. Dysregulation of glutathione synthesis in psychiatric disorders
15. Role of nitrative stress in brain of schizophrenic patients
16. Blood platelet as a peripheral cell in oxidative stress in psychiatric diseases
17. Mitochondrial dysfunction in autism
18. Ultrasound and Autism: How Disrupted Redox Homeostasis and Transient Membrane Porosity Confer Risk
19. Animal Model of Autistic Regression: Link to Toxicant-Induced Oxidative Stress
20. Genetic Polymorphism Related to Oxidative Stress in Autism
21. Telomere length in major psychiatric disorders. Is there any relationship between telomere length and oxidative stress?
22. The impact of oxidative stress on GAD67 levels and parvalbumin - positive neurons
23. The possible role of iron in neurodegeneration
24. Oxidation stress and polyunsaturated lipid peroxidation products in the CNS: focus
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on DHA-derived fragment
Part 3. Therapeutic aspects
25. Antioxidant interventions in neuropsychiatric disorders
26. Antioxidant plant polyphenols and cognitive disorders
27. Hyperbaric oxygen treatment in autism spectrum disorders
28. Effects of lithium on oxidative stress
29. Cryostimulation as adjunct treatment in psychiatric disorders
Index
Part 3. Therapeutic aspects
25. Antioxidant interventions in neuropsychiatric disorders
26. Antioxidant plant polyphenols and cognitive disorders
27. Hyperbaric oxygen treatment in autism spectrum disorders
28. Effects of lithium on oxidative stress
29. Cryostimulation as adjunct treatment in psychiatric disorders
Index
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Autoren-Porträt
Anna Dietrich-Muszalska MD, PhD is a professor of psychiatry at the Medical University of Lodz, Poland. She is the Head of the Department of Biological Psychiatry of the Chair of Experimental and Clinical Physiology, Medical University of Lodz, and the Head of the Centre of Prevention and Treatment Addiction of Narcotics in Lodz. She receivied her training in psychiatry at Clinical Psychiatry in the Department of Psychiatry at the Medical University of Lodz . Dr. Dietrich-Muszalska received an MD (specialist of Psychiatry and specialist of Child and Adolescent Psychiatry), a PhD in 1997, and a professorship in 2014 at Medical University of Lodz. Her research interest concerns the development of new and improved treatments of schizophrenia. Her clinical research is focused on understanding the pathophysiology of schizophrenia and includes clinical, pharmacological, and neurochemical aspects of schizophrenia. She is especially interested in the oxidative stress and oxidative and nitrosative changes in schizophrenic patients and the relationship between drug addiction and psychiatric disorders. Dr. Dietrich-Muszalska has published more than 74 research articles and book chapters.Ved Chauhan PhD is Head of the Cellular Neurochemistry Laboratory at the New York State Institute for Basic Research in Developmental Disabilities (IBR), Staten Island, NY. Dr. Chauhan received his MS (Biochemistry) in 1975 and PhD (Biochemistry) in 1980 from the Postgraduate Institute for Medical Education and Research, Chandigarh, India. After working as a Research Associate for two years in the Department of Biochemistry at the University of Southern California, Los Angeles, CA, he joined IBR as a research scientist in 1983. Dr. Chauhan has published more than 83 research articles in peer-reviewed journals. His work includes biochemical abnormalities in autism, the role of phosphoinositides in the activation of protein kinase C, and factors affecting the
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fibrillization of amyloid beta-protein. He has been recipient of research grants from National Institutes of Health, Alzheimer's Association, Autism Speaks and Autism Research Institute. Dr. Chauhan has served as a co-editor of a book entitled Autism: Oxidative stress, inflammation and immune abnormalities. Dr. Chauhan is Associate Editor of the Journal of Alzheimer's disease and an Editorial Board member of International Archives of Medicine. He has organized and chaired several national and international symposia on autism.
Sylvain Grignon MD, PhD is a Professor of Psychiatry, Physiology & Biophysics at Sherbrooke University, Québec, Canada. Dr Grignon received his MD, certification in Psychiatry (1991) and PhD (1996, Neuroscience) at Marseilles University, France, and postdoctoral training at Georgetown University (Neuroscience) and Marseilles University (Pharmacology). He joined Sherbrooke University in 2003 and is currently full professor and Research Head, Department of Psychiatry. In parallel with clinical duties (including medical chief of the psychotic disorders program 2004-2012), he maintains an active research program, whose overarching aim is to understand how oxidative stress impacts pathophysiological processes in major psychiatric disorders such as schizophrenia and bipolar affective disorder. Dr Grignon has published more than 50 original papers and book chapters.
Sylvain Grignon MD, PhD is a Professor of Psychiatry, Physiology & Biophysics at Sherbrooke University, Québec, Canada. Dr Grignon received his MD, certification in Psychiatry (1991) and PhD (1996, Neuroscience) at Marseilles University, France, and postdoctoral training at Georgetown University (Neuroscience) and Marseilles University (Pharmacology). He joined Sherbrooke University in 2003 and is currently full professor and Research Head, Department of Psychiatry. In parallel with clinical duties (including medical chief of the psychotic disorders program 2004-2012), he maintains an active research program, whose overarching aim is to understand how oxidative stress impacts pathophysiological processes in major psychiatric disorders such as schizophrenia and bipolar affective disorder. Dr Grignon has published more than 50 original papers and book chapters.
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Bibliographische Angaben
- 2015, 2015, XX, 596 Seiten, 17 farbige Abbildungen, Masse: 16,5 x 24,2 cm, Gebunden, Englisch
- Herausgegeben: Anna Dietrich-Muszalska, Ved Chauhan, Sylvain Grignon
- Verlag: Springer, Berlin
- ISBN-10: 1493904396
- ISBN-13: 9781493904396
Sprache:
Englisch
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