Single Nucleotide Polymorphisms

to Single Nucleotide Polymorphisms.- SNPs: Impact on Gene Function and Phenotype.- Silent (Synonymous) SNPs: Should We Care About Them?.- Bioinformatic Analysis of SNPs.- SNP Databases.- Mining SNPs from DNA Sequence Data; Computational Approaches to SNP Discovery and Analysis.- SNP Identification and Detection Strategies: Whole Genome Sequencing and Re-Sequencing.- Next-Generation Sequencing Methods: Impact of Sequencing Accuracy on SNP Discovery.- Scanning Probe and Nanopore DNA Sequencing: Core Techniques and Possibilities.- Pyrosequencing for SNP Genotyping.- Prescreening (Melting Based) Methods for SNP Discovery and Analysis.- Single Nucleotide Polymorphism Screening with Denaturing Gradient Gel Electrophoresis.- Temporal Temperature Gradient Electrophoresis for Detection of Single Nucleotide Polymorphisms.- Prescreening (Conformation Based) Methods for SNP Discovery and Analysis.- Zn(II)-Cyclen Polyacrylamide Gel Electrophoresis for SNP Detection.- Phosphate-Affinity Polyacrylamide Gel Electrophoresis for SNP Genotyping.- Estimation of SNP Allele Frequencies by SSCP Analysis of Pooled DNA.- Phenylethynylpyrene Excimer Forming Hybridization Probes for Fluorescence SNP Detection.- The Chemical Cleavage of Mismatch for the Detection of Mutations in Long DNA Fragments.- Mismatch Oxidation Assay: Detection of DNA Mutations Using a Standard UV/Vis Microplate Reader.- Towards High-Throughput Methods of SNP Genotyping.- High-Throughput Methods for SNP Genotyping.- High-Throughput SNP Genotyping: Combining Tag SNPs and Molecular Beacons.- SNP Genotyping by the 5?-Nuclease Reaction: Advances in High-Throughput Genotyping with Nonmodel Organisms.- The TaqMan Method for SNP Genotyping.- Qualitative and Quantitative Genotyping Using Single Base Primer Extension Coupledwith Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MassARRAY®).- SNP Detection Using Trityl Mass Tags.- Putting the Invader® Assay to Work: Laboratory Application and Data

From the reviews of the second edition:"This second edition brings 11 new chapters ... . Its target audience continues to be researchers and laboratory personnel. One helpful feature the book includes is a set of 'notes' at the end of each chapter ... to be very useful for readers choosing to utilize a technique for the first time. ... Overall, this book is a good addition to any laboratory setting actively working on complex human traits or interested in personalized medicine and drug treatments." (Alexandre R. Vieira, Birth Defects Research (Part A): Clinical and Molecular Teratology, Vol. 88 (12), 2010)

From the reviews of the second edition:"This second edition brings 11 new chapters ... . Its target audience continues to be researchers and laboratory personnel. One helpful feature the book includes is a set of 'notes' at the end of each chapter ... to be very useful for readers choosing to utilize a technique for the first time. ... Overall, this book is a good addition to any laboratory setting actively working on complex human traits or interested in personalized medicine and drug treatments." (Alexandre R. Vieira, Birth Defects Research (Part A): Clinical and Molecular Teratology, Vol. 88 (12), 2010)