Signal Transduction and the Coordination of B Lymphocyte Development and Function I
Transduction of BCR Signals from the Cell Membrane to the Nucleus
(Sprache: Englisch)
Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of...
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Klappentext zu „Signal Transduction and the Coordination of B Lymphocyte Development and Function I “
Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.
Inhaltsverzeichnis zu „Signal Transduction and the Coordination of B Lymphocyte Development and Function I “
Signal Transduction via the B-cell Antigen Receptor: The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphates- The B-Cell Antigen Receptor: Formation of Signaling Complexes and the Function of Adaptor Proteins
- Intermediary Signaling Effectors Coupling the B-Cell Receptor to the Nucleus
- Involvement of the Lymphocyte Cytoskeleton in Antigen-Receptor Signaling
- Pax-5/BSAP: Regulator of Specific Gene Expression and Differentiation in B Lymphocytes
- Receptor Modulators of B-Cell Receptor Signalling - CD19/ CD22
- Positive and Negative Signaling in B Lymphocytes.
Bibliographische Angaben
- 2000, XV, 267 Seiten, Masse: 16,3 x 24,2 cm, Gebunden, Englisch
- Herausgegeben: Louis B. Justement, Katherine A. Siminovitch
- Verlag: Springer, Berlin
- ISBN-10: 354066002X
- ISBN-13: 9783540660026
Sprache:
Englisch
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