RNA Technologies in Cardiovascular Medicine and Research

Preface.- Part I - MicroRNA.- An overview of microRNA. MicroRNAs and their potential. miRNAs and their emerging role in cardiac hypertrophy. MicroRNAs and the control of heart pathophysiology. MicroRNA systems biology.- Part II - RNA interference.- Targeting viral heart disease by RNA interference. Design of siRNAs and shRNAs for RNA interference: possible clinical applications. RNA interference and microRNA modulation for the treatment of cardiac disorders. Cardiac delivery of nucleic acids by transcriptional and transductional targeting of adeno-associated viral vectors.- Part III - Ribozymes.- Characterization of hammerhead ribozymes potentialy suitable for the treatment of hyperproliferative vascular diseases. Applications of ribozymes and pyrrole-imidazole polyamides for cardiovascular and renal diseases.- Part IV. - Noncoding, aptamer and antisense RNAs.- Noncoding RNAs in human diseases. Aptamers and siRNAs in cardiovascular disease. Nucleic Acid Aptamers for Cardiovascular Therapeutics. NFkB decoy oligodeoxynucleotide-based therapy in cardiovascular diseases. Antisense therapy for restenosis following percutaneous coronary intervention.Toxic RNA in pathogenesis of human neuromuscular disorders.