RNA Interference

Physiology of RNA Interference.- Endogenous Antiviral Mechanisms of RNA Interference: A Comparative Biology Perspective.- Monitoring Innate Immune Recruitment by siRNAs in Mammalian Cells.- Current Knowledge of MicroRNAs and Noncoding RNAs in Virus-Infected Cells.- Allele-Specific Silencing by RNA Interference.- Computational siRNA Design Considering Alternative Splicing.- Bioinformatic Approaches to siRNA Selection and Optimization.- Optimized Gene Silencing by Co-expression of Multiple shRNAs in a Single Vector.- Strategies in Designing Multigene Expression Units to Downregulate HIV-1.- Designing Optimal siRNA Based on Target Site Accessibility.- Chemical Synthesis of 2?-O-Alkylated siRNAs.- RNA Interference in the Laboratory and siRNA Delivery.- siRNA Specific Delivery System for Targeting Dendritic Cells.- Hydrodynamic Delivery Protocols.- New Methods for Reverse Transfection with siRNA from a Solid Surface.- Nonviral siRNA Delivery for Gene Silencing in Neurodegenerative Diseases.- Using siRNA to Uncover Novel Oncogenic Signaling Pathways.- Biodegradable Polymer-Mediated sh/siRNA Delivery for Cancer Studies.- Cellular siRNA Delivery Using TatU1A and Photo-Induced RNA Interference.- Polyethylenimine (PEI)/siRNA-Mediated Gene Knockdown In Vitro and In Vivo.- Transfection of siRNAs in Multiple Myeloma Cell Lines.- Clinical Implementation.- A New Approach for Therapeutic Use by RNA Interference in the Brain.- Inhibitory RNA Molecules in Immunotherapy for Cancer.- Preventing Tissue Injury Using siRNA.- Preventing Immune Rejection Through Gene Silencing.- Topical Application of siRNA Targeting Cutaneous Dendritic Cells in Allergic Skin Disease.- Direct Application of siRNA for In Vivo Pain Research.- A Potential Therapeutic for Pandemic Influenza Using RNAInterference.- Evaluation of Targets for Ovarian Cancer Gene Silencing Therapy: In Vitro and In Vivo Approaches.

From the reviews:"The book provides a broad overview of RNA chemistry, the pharmacology and the manipulation of signaling pathways by using RNA interference. ... This book is very well written and will be an asset to any researcher who uses RNA interference as a tool to study gene function. ... and will probably mainly be of use to researcher already working in the field and familiar with different techniques of siRNA delivery." (Anna Vossenkaemper, Immunology News, November, 2010)