RNA/DNA and Cancer

Preface. Introductions. I   THE PRIMORDIAL RNA/DNA COMPLEX EVOLVING.- The Primordial Genes  Are Conserved as Stem  Cell Genes and Proto-Oncogenes.- The First Cells Ascend.-  Eukaryotic Single Cells and the First Cell Communities Then and Now.-  A Highly Effective Immune System Predating Adaptive Immunity.- Elements of Adaptive Immunity Self-Assemble.- The RNA/DNA Complex at Work.- YY Proteins.- Elusive Alleles.- The Long Trajectory of the IGF-like Receptor and Its Ligands.- Primordial Fused Genes Become Oncogenes and Encode Oncoproteins.- Performance in the Laboratory.- Inbuilt Errors not yet Corrected.- Errors or Inherent Attributes for the Sustenance of Unicellular Life.- Viral Genomic Insertions into the Host Cell's Genome.- Viral and Cellular Proteins Interact.- Light Cast to Broken DNA, Its Repair, and Consequences.- Undisciplined Introns.- Elementary Epigenomics.- RNA/DNA: Bioengineers Supreme.- II  THE ONCOGENOME.- Seamless Unity of the Nucleus and Cytoplasm: the Membranes Are Permeable.- Endogenously Initiated Immortalization is Welcome. Enforced Carcinogenesis by Exogenous Alien Initiator Is Resisted.- A Condensed Compendium.- "Malignant Transformation".- III  THE HUMAN CEREBRAL CORTICAL DNA AGAINST CANCER CELL DNA.- Will the Human Cerebral Cortex Subdue the Oncogenome?- In Self-Defense, the Cancer Cell Reactivates Its Primordial Genome Loaded with    Proviruses in Order to Mobilize All Its Remaining Survival Pathways.- The Cancer Cell Viewed as a Unicellular Parasite (an Amoeba).-      Astute Observers Withstand Derision.- "Making Cancer History" at M.D. Anderson Hospital.- SUMMARY.- Appendix 1.-Appendix 2.- Index.

 

Joseph G. Sinkovics, the author of this book, was born and educated in Budapest, Hungary. As a medical student in the 1940s at the Péter Pázmány University Medical Faculty (now Semmelweis Medical University), he worked at the University Institute of Pathophysiology with Haemobartonella muris on splenectomized rats. He received his medical doctorate (MD) degree summa cum laude in 1948. He continued working as adjunct professor at the University Institute of Microbiology and as a senior virologist and board-certified clinical pathologist at the State Institute of Public Health in Budapest. His publications in German and English on bacterial L-forms and spheroplasts, and on influenza, mumps and Newcastle disease viruses (NDV) appeared in the Acta Microbiologica Hungarica and in the Archive für die Gesamte Virusforschung. One of these publications described the oncolytic effect of NDV in Ehrlich ascites carcinoma in mice. In another publication that appeared in Nature, bacterial spheroplasts were described to pass filters, undergo fusions and regenerate into vegetative cells. The Hungarian Akadémiai Kiadó published Sinkovics' monograph under the title "Die Grundlagen der Virusforschung" in 1956. After the demolition of the popular Hungarian uprising in 1956, Sinkovics had to leave Hungary for Vienna, Austria. From there he entered the United States, where he was sponsored by Albert Sabin for a Rockefeller Fellowship. He spent one year (1957) as a Rockefeller Fellow at the Waksman Institute at Rutgers, The State University of New Jersey. In order to validate his medical degree and diploma in the USA, he served medical internship and residency in internal medicine, infectious diseases and hematology at the Cook County Hospital, Cook County School of Medicine, the Hektoen Institute for Medical Research in Chicago IL, and in hematology-medical oncology at The University of Texas M.D. Anderson Hospital, Houston TX (1958-1962). In 1962 he nt-size: 13.3333px;">was enrolled