Rational Drug Design
Methods and Protocols
(Sprache: Englisch)
This Methods in Molecular Biology(TM) book details rational drug design, including virtual screening of chemical hits, lead discovery by high throughput screening, combinatorial and fragment based lead generation, peptide based drug discovery and animal models.
Jetzt vorbestellen
versandkostenfrei
Buch (Gebunden)
Fr. 118.00
inkl. MwSt.
- Kreditkarte, Paypal, Rechnungskauf
- 30 Tage Widerrufsrecht
Produktdetails
Produktinformationen zu „Rational Drug Design “
This Methods in Molecular Biology(TM) book details rational drug design, including virtual screening of chemical hits, lead discovery by high throughput screening, combinatorial and fragment based lead generation, peptide based drug discovery and animal models.
Klappentext zu „Rational Drug Design “
This Methods in Molecular Biology(TM) book details rational drug design, including virtual screening of chemical hits, lead discovery by high throughput screening, combinatorial and fragment based lead generation, peptide based drug discovery and animal models.
Inhaltsverzeichnis zu „Rational Drug Design “
1. On Setting up and Assessing Docking Simulations for Virtual ScreeningJacek Biesiada, Aleksey Porollo, Jaroslaw Meller 2. Virtual Ligand Screening Combined with NMR to Identify Dvl PDZ Domain Inhibitors Targeting the Wnt SignalingJufang Shan and Jie J. Zheng 3. Rational Design of Rho GTPase Targeting InhibitorsXun Shang and Yi Zheng 4. Rational Design of Peptide Ligands Against a Glycolipid by NMR StudiesWenyong Tong, Tara Sprules, Kalle Gehring, H. Uri Saragovi 5. A Combinatorial Strategy for the Acquisition of Potent and Specific Protein Tyrosine Phosphatase InhibitorsSheng Zhang, Lan Chen, David S. Lawrence and Zhong-Yin Zhang 6. Identification of Allosteric Inhibitors of p21-Activated KinaseJulien Viaud and Jeffrey R. Peterson 7. Using a Modified Yeast Two-hybrid System to Screen for Chemical GEF InhibitorsAnne Blangy and Philippe Fort . 8. Random Mutagenesis of Peptide Aptamers As An Optimization Strategy for Inhibitor ScreeningNathalie Bouquier, Sylvie Fromont, Anne Debant and Susanne Schmidt 9. A Screening Strategy for Trapping the Inactive Conformer of a Dimeric Enzyme with a Small Molecule InhibitorTina Shahian and Charles S. Craik 10. Use of a Fluorescent ATP Analog to Probe the Allosteric Conformational Change in the Active Site of the Protein Kinase PDK1Valerie Hindie, Laura A. Lopez-Garcia, and Ricardo M. Biondi 11. Affinity Purification of Protein Kinases that Adopt a Specific Inactive ConformationPratistha Ranjitkar and Dustin J. Maly 12. Determination of the Kinetics and Thermodynamics of Ligand Binding to a Specific Inactive Conformation in Protein KinasesSanjay B. Hari, Pratistha Ranjitkar and Dustin J. Maly 13. Purification and Specific Assays for Measuring APE-1 Endonuclease ActivityAdrian Esqueda, Mohammed Z Mohammed, Srinivasan Madhusudan, and Nouri Neamati 14. An in vitro Screening to Identify Drug Resistant Mutations for Target-directed Chemotherapeutic AgentsMohammad
... mehr
Azam 15. Utilizing AntagomiR (anti-sense microRNA) to Knock Down microRNA in Murine Bone Marrow CellsChinavenmeni S. Velu and H. Leighton Grimes 16. Synthesis, Conjugation, and Labeling of Multifunctional pRNA Nanoparticles for Specific Delivery of siRNA, Drugs and Other Therapeutics to Target CellsMathieu Cinier, Yi Shu, Daniel Binzel, and Peixuan Guo 17. Mouse Models for Tumor MetastasisShengyu Yang, J. Jillian Zhang, and Xin-Yun Huang1. On Setting up and Assessing Docking simulations for Virtual ScreeningJacek Biesiada, Aleksey Porollo, Jaroslaw Meller 2. Virtual Ligand Screening Combined with NMR to Identify Dvl PDZ Domain Inhibitors Targeting the Wnt SignalingJufang Shan and Jie J. Zheng 3. Rational Design of Rho GTPase Targeting InhibitorsXun Shang and Yi Zheng 4. Rational Design of Peptide Ligands Against a Glycolipid by NMR StudiesWenyong Tong, Tara Sprules, Kalle Gehring, H. Uri Saragovi 5. A Combinatorial Strategy for the Acquisition of Potent and Specific Protein Tyrosine Phosphatase InhibitorsSheng Zhang, Lan Chen, David S. Lawrence and Zhong-Yin Zhang 6. Identification of Allosteric Inhibitors of p21-Activated KinaseJulien Viaud and Jeffrey R. Peterson 7. Using a Modified Yeast Two-hybrid System to Screen for Chemical GEF InhibitorsAnne Blangy and Philippe Fort . 8. Random Mutagenesis of Peptide Aptamers As An Optimization Strategy for Inhibitor ScreeningNathalie Bouquier, Sylvie Fromont, Anne Debant and Susanne Schmidt 9. A Screening Strategy for Trapping the Inactive Conformer of a Dimeric Enzyme with a Small Molecule InhibitorTina Shahian and Charles S. Craik 10. Use of a Fluorescent ATP Analog to Probe the Allosteric Conformational Change in the Active Site of the Protein Kinase PDK1Valerie Hindie, Laura A. Lopez-Garcia, and Ricardo M. Biondi 11. Affinity Purification of Protein Kinases that Adopt a Specific Inactive ConformationPratistha Ranjitkar and Dustin J. Maly 12. Determination of the Kinetics and Thermodynamics of Ligand Binding to a Specific Inactive Conformation in Protein KinasesSanjay B. Hari, Pratistha Ranjitkar and Dustin J. Maly 13. Purification and Specific Assays for Measuring APE-1 Endonuclease ActivityAdrian Esqueda, Mohammed Z Mohammed, Srinivasan Madhusudan, and Nouri Neamati 14. An in vitro Screening to Identify Drug Resistant Mutations for Target-directed Chemotherapeutic AgentsMohammad Azam 15. Utilizing AntagomiR (anti-sense microRNA) to Knock Down microRNA in Murine Bone Marrow CellsChinavenmeni S. Velu and H. Leighton Grimes 16. Synthesis, Conjugation, and Labeling of Multifunctional pRNA Nanoparticles for Specific Delivery of siRNA, Drugs and Other Therapeutics to Target CellsMathieu Cinier, Yi Shu, Daniel Binzel, and Peixuan Guo 17. Mouse Models for Tumor MetastasisShengyu Yang, J. Jillian Zhang, and Xin-Yun Huang1. On Setting up and Assessing Docking simulations for Virtual ScreeningJacek Biesiada, Aleksey Porollo, Jaroslaw Meller 2. Virtual Ligand Screening Combined with NMR to Identify Dvl PDZ Domain Inhibitors Targeting the Wnt SignalingJufang Shan and Jie J. Zheng 3. Rational Design of Rho GTPase Targeting InhibitorsXun Shang and Yi Zheng 4. Rational Design of Peptide Ligands Against a Glycolipid by NMR StudiesWenyong Tong, Tara Sprules, Kalle Gehring, H. Uri Saragovi 5. A Combinatorial Strategy for the Acquisition of Potent and Specific Protein Tyrosine Phosphatase InhibitorsSheng Zhang, Lan Chen, David S. Lawrence and Zhong-Yin Zhang 6. Identification of Allosteric Inhibitors of p21-Activated KinaseJulien Viaud and Jeffrey R. Peterson 7. Using a Modified Yeast Two-hybrid System to Screen for Chemical GEF InhibitorsAnne Blangy and Philippe Fort . 8. Random Mutagenesis of Peptide Aptamers As An Optimization Strategy for Inhibitor ScreeningNathalie Bouquier, Sylvie Fromont, Anne Debant and Susanne Schmidt 9. A Screening Strategy for Trapping the Inactive Conformer of a Dimeric Enzyme with a Small Molecule InhibitorTina Shahian and Charles S. Craik 10. Use of a Fluorescent ATP Analog to Probe the Allosteric Conformational Change in the Active Site of the Protein Kinase PDK1Valerie Hindie, Laura A. Lopez-Garcia, and Ricardo M. Biondi 11. Affinity Purification of Protein Kinases that Adopt a Specific Inactive ConformationPratistha Ranjitkar and Dustin J. Maly 12. Determination of the Kinetics and Thermodynamics of Ligand Binding to a Specific Inactive Conformation in Protein KinasesSanjay B. Hari, Pratistha Ranjitkar and Dustin J. Maly 13. Purification and Specific Assays for Measuring APE-1 Endonuclease ActivityAdrian Esqueda, Mohammed Z Mohammed, Srinivasan Madhusudan, and Nouri Neamati 14. An in vitro Screening to Identify Drug Resistant Mutations for Target-directed Chemotherapeutic AgentsMohammad Azam 15. Utilizing AntagomiR (anti-sense microRNA) to Knock Down microRNA in Murine Bone Marrow CellsChinavenmeni S. Velu and H. Leighton Grimes 16. Synthesis, Conjugation, and Labeling of Multifunctional pRNA Nanoparticles for Specific Delivery of siRNA, Drugs and Other Therapeutics to Target CellsMathieu Cinier, Yi Shu, Daniel Binzel, and Peixuan Guo 17. Mouse Models for Tumor MetastasisShengyu Yang, J. Jillian Zhang, and Xin-Yun Huang
... weniger
Bibliographische Angaben
- 2012, 2012, XI, 230 Seiten, 22 farbige Abbildungen, Masse: 18,3 x 26 cm, Gebunden, Englisch
- Herausgegeben: Yi Zheng
- Verlag: Springer, Berlin
- ISBN-10: 1627030077
- ISBN-13: 9781627030076
- Erscheinungsdatum: 06.09.2012
Sprache:
Englisch
Rezension zu „Rational Drug Design “
From the reviews:"This book covers some of the tools and techniques involved in rational drug design with a series of case studies designed to act as a compendium of methods and protocols intended for readers to adopt or modify. ... The book would therefore make interesting reading to any student or investigator looking to gain a wider appreciation of strategies and activities across different disciplines or unfamiliar projects in the early drug discovery phase as well as the primary target audience of organic/medicinal chemists and molecular biologists." -- Stefan Kavanagh, BTS Newsletter - The British Toxicology Society, Issue 43, Winter, 2013
Pressezitat
From the reviews:"This book covers some of the tools and techniques involved in rational drug design with a series of case studies designed to act as a compendium of methods and protocols intended for readers to adopt or modify. ... The book would therefore make interesting reading to any student or investigator looking to gain a wider appreciation of strategies and activities across different disciplines or unfamiliar projects in the early drug discovery phase as well as the primary target audience of organic/medicinal chemists and molecular biologists." (Stefan Kavanagh, BTS Newsletter - The British Toxicology Society, Issue 43, Winter, 2013)
Kommentar zu "Rational Drug Design"
0 Gebrauchte Artikel zu „Rational Drug Design“
Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
---|
Schreiben Sie einen Kommentar zu "Rational Drug Design".
Kommentar verfassen