Questions in Daily Urologic Practice

Prostate.- Does a prostatic capsule exist? Pathologists and urologists use the word "capsule" when evaluating the extent of prostatic cancer in prostatectomy specimens.- What is the anatomic structure of the prostate? Where is the transition zone? Where does carcinoma develop? Where does benign prostatic hyperplasia occur?.- What is the clinical significance of perineural invasion reported on prostate needle core biopsy?.- What is the difference between a positive surgical margin and extraprostatic extension in pathology reports of radical prostatectomy? What is the clinical relevance of these findings?.- What is the clinical significance of prostate cancer incidentally discovered in tissue removed to relieve urinary tract obstruction mostly by transurethral resection (stage T1a and T1b cancers)?.- What are the characteristics of transition zone cancer? Is it less aggressive than the non-transition-zone cancer?.- Is there a significant difference in prognosis between Gleason score 3 + 4 and 4 + 3 prostate cancers in radical prostatectomy specimens? What is the prognostic implication of Gleason score 3 + 4 versus 4 + 3 prostate cancer assigned to prostate needle core biopsy specimens?.- A positive surgical margin associated with an extraprostatic extension of prostate carcinoma is a significant risk for disease progression. What, then, is the risk of a positive margin created by an inadvertent surgical incision into cancerous prostate parenchyma?.- What are the neuroendocrine cells in prostate cancer? From where are these cells derived? What is the clinical implication of neuroendocrine differentiation in prostate cancer?.- What is prostatic ductal adenocarcinoma? How is it clinically and pathologically different from the conventional (acinar) adenocarcinoma?.- What immunohistochemical markers are useful for the diagnosis of prostate cancer?.- When a basal cell-specific marker (34?E12 or p63) is negative in an atypical focus, can the diagnosis of adenocarcinoma be

From the reviews:



"The book is authored by 2 pathologists and 1 urologist and contains 5 parts spanning 287 pages. ... the book is user-friendly and an easy read. It contains detailed and high-quality photographs. This book will prove useful to resident physicians in pathology and urology, as well as have pragmatic value to general pathologists." (Navin C. Shah and Isabell Sesterhenn, Journal of the American Medical Association, December, 2008)

"This book focuses on important questions about malignant diseases of the prostate, kidney, bladder, testes, and adrenal glands faced by urologists. ... The book is written for the benefit of both clinical urologists and diagnostic surgical pathologists. Residents also will benefit from the broad array of relevant questions ... . By focusing on the questions asked by practicing urologists, this book offers a source of easily referenced, valuable information for physicians managing patients with urologic malignancies." (Nicholas T Leone, Doody's Review Service, May, 2009)

"This book attempts to answer various questions in the practice of Uro-Oncology. ... The questions and answers format is very interesting, with detailed comments and references. ... I conclude by saying that this book is a must read for all exam preparing post graduates. Lot of information they get by wide search are concentrated in single hand book. This is a good reference book for practicing urologists ... . Well updated book for all pathologists, practicing Uro-Pathology." (Urology, Vol. 74 (3), September, 2009)