PLGA Micro and nanoparticles for Cancer Treatment

Poly (lactide-glycolide) particles were synthesized by solvent evaporation method with two methods to obtain particles of different size. By changing the percentage of polymer in dispersed phase solution and percentage of poly (vinyl alcohol) in continuous phase, particles with different morphology and dimensions were prepared. The particles with a low percentage of stabilizer had rough surfaces and larger sizes. By increasing the percentage of polymer in the dispersed phase from 1 to 2%, the particle size first decreased and then increased. As the process conditions changed, sub-micron-sized particles were made from PLGA solutions of varying concentrations in 1% poly (vinyl alcohol) solution. The results indicate the high sensitivity of the morphology and dimensions of poly (lactide-glycolide) particles to the manufacturing process conditions. The sub-micron particles were loaded with the anti-cancer drug Oxaliplatin. Drug loading rate was a function of dispersed phase viscosityand droplet dimensions. The release test showed the ability of the particles prepared to control and delay release of Oxaliplatin in the release medium for 96 hours.