Outbreak in the Village

1. Introduction.- 2. From Africa to England.- 3. The children's clinic at Keyworth.- 4. Whooping cough vaccine.- 5. 1977-79: The first outbreak of whooping cough.- 6. Does the vaccine work?.- 7. 1981: Whooping cough vaccine is very rarely harmful.- 8. 1981-83: The second outbreak. How many cases are there really?.- 9.1985-87: The third outbreak. The search for subclinical infection.- 10. Does the effectiveness of the vaccine wear off?.- 11. 1988: Trying to raise the uptake of pertussis vaccine.- 12. 1989-91: The fourth outbreak. The natural history of whooping cough.- 13. 1990's: Whooping cough fades away but new diagnostic tests emerge.- 14. 2000: Whoopingcough.net. Overcoming diagnostic paralysis.- 15. The early noughties: The new tests aid the rediscovery of whooping cough.- 16. Late noughties: "Resurgence" of whooping cough in the USA and Australia puts the UK on alert.- 17. 2012: Whooping cough diagnoses peak in the UK but remain unchanged in Keyworth.- 18. What lies ahead?.- 19.Epilogue.- Appendix.

Douglas Jenkinson was brought up on the Wirral peninsula in north-west England and attended Calday Grange Grammar school. He graduated from Liverpool Medical School in 1967. After three years in junior posts in medicine, surgery, pediatrics, and obstetrics and gynecology, he went to Zambia with his family where he spent three years doing general medical duties, obstetrics and gynecology, and neonatal pediatrics. There he discovered his love of research. He returned to the UK in 1973 to join a General Medical Practice partnership in rural Nottinghamshire where, in 1977, he investigated a large outbreak of whooping cough and was the first in 30 years to confirm the benefit of pertussis immunisation. He became a part-time lecturer in General Practice at Nottingham Medical School in 1979, and in 1988 with Professor Idris Williams, set up the first M.Med.Sci. course. He researched and published papers on asthma in addition to whooping cough and sat on the Medical Advisory Committee to the Asthma Society and Friends of the Asthma Research Council. He contributed to textbooks on asthma and child health. He was awarded a doctorate for his whooping cough research in 1996 and continued to research whooping cough after he retired from Keyworth Medical practice in 2011. He has a popular website to help patients with whooping cough get a diagnosis.