Molecular Mechanisms in Legionella Pathogenesis
(Sprache: Englisch)
This book examines different facets of Legionnaires' disease, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses.
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This book examines different facets of Legionnaires' disease, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses.
Klappentext zu „Molecular Mechanisms in Legionella Pathogenesis “
Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila . This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila . Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila .Inhaltsverzeichnis zu „Molecular Mechanisms in Legionella Pathogenesis “
From amoeba to macrophages: exploring the molecular mechanisms of Legionella infection in both hosts.- The Legionella pneumophila two-component regulatory systems that participate in the regulation of Icm/Dot effectors.- Facets of small RNA-mediated regulation in Legionella pneumophila.- Type II secretion and Legionella virulence.- Effector translocation by the Legionella Icm/Dot type IV secretion system.- Modulation of small GTPases by Legionella.- Host lipidation: A mechanism for spatial regulation of Legionella effectors.- Phosphoinositides and the Legionella pathogen vacuole.- Legionella phospholipases implicated in virulence.- Cytotoxic glucosyltransferases of Legionella pneumophila.- Modulation of the ubiquitination machinery by Legionella.- Host signal transduction and protein kinases implicated in Legionella infection.- Mouse models of Legionnaires´ disease.
Bibliographische Angaben
- 2016, Softcover reprint of the original 1st ed. 2014, X, 295 Seiten, 2 farbige Abbildungen, Masse: 15,5 x 23,5 cm, Kartoniert (TB), Englisch
- Herausgegeben: Hubert Hilbi
- Verlag: Springer, Berlin
- ISBN-10: 3662523000
- ISBN-13: 9783662523001
Sprache:
Englisch
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