Microarray Methods for Drug Discovery

Multicenter Clinical Sample Collection for Microarray Analysis.- Isolation of Total RNA from Transgenic Mouse Melanoma Subsets Using Fluorescence-Activated Cell Sorting.- Microarray Analysis of Embryonic Stem Cells and Differentiated Embryoid Bodies.- Determination of Alternate Splicing Events Using the Affymetrix Exon 1.0 ST Arrays.- Profiling microRNA Expression with the Illumina BeadChip Platform.- TaqMan® Array Cards in Pharmaceutical Research.- DMET(TM) Microarray Technology for Pharmacogenomics-Based Personalized Medicine.- The Use of Microarray Technology for Cytogenetics.- PCR/LDR/Universal Array Platforms for the Diagnosis of Infectious Disease.- RIP-CHIP in Drug Development.- ChIPing Away at Global Transcriptional Regulation.- HELP (HpaII Tiny Fragment Enrichment by Ligation-Mediated PCR) Assay for DNA Methylation Profiling of Primary Normal and Malignant B Lymphocytes.- High-Throughput Screening of Metalloproteases Using Small Molecule Microarrays.- Metabolic Enzyme Microarray Coupled with Miniaturized Cell-Culture Array Technology for High-Throughput Toxicity Screening.- Use of Tissue Microarray to Facilitate Oncology Research.- Small Molecule Selectivity and Specificity Profiling Using Functional Protein Microarrays.- Production and Application of Glycan Microarrays.

From the reviews:

"Microarray Methods for Drug Discovery is volume number 632 of the Springer Protocols Methods in Biology Series. ... it provides detailed experimental protocols for the use of microarrays in a variety of applications. ... chapters are obviously highly bespoke and would be of real value to laboratories wishing to establish the method. Finally, the microarray area is now so broad that the non-nucleic acid application of microarrays would justify a methods book in its own right." (James Sidaway, BTS Newsletter, Issue 37, Winter, 2010)

"Methods in Microarrays provide scientists with a complete resource on the most effective tools available for maximizing microarray data in biochemical methods. ... Microarrays are extensively used in the effects of compounds on gene expression in cells. This book aims at enlightening individuals of all levels of experience about some of the most common applications of microarrays in drug discovery and development. This book will serve as a reference for students and scientists ... ." (Veni Maria Andres Felli, Brazilian Journal of Pharmaceutical Sciences, May, 2010)