Kinase Inhibitors

Targeting Cancer with Small Molecular Weight Kinase Inhibitors.- Small Molecule Protein and Lipid Kinase Inhibitors in Inflammation and Specific Models for their Evaluation.- Measuring the Activity of Leucine Rich Repeat Kinase 2 (LRRK2) - A Kinase Involved in Parkinson's Disease.- Measuring PI3K Lipid Kinase Activity.- A Fluorescence Polarization Assay for the Discovery of Inhibitors of the Polo-box Domain of Polo-like Kinase 1.- Assessment of Hepatotoxicity Potential of Drug Candidate Molecules Including Kinase Inhibitors by Hepatocyte Imaging Assay Technology and Bile Flux Imaging Assay Technology.- Kinase Inhibitor Selectivity Profiling using Differential Scanning Fluorimetry.- Chemoproteomic Characterization of Protein Kinase Inhibitors using Immobilized ATP.- Proteome-wide identification of staurosporine-binding kinases using Capture Compound Mass Spectrometry.- Affinity Purification of Proteins Binding to Kinase Inhibitors Immobilised on Self Assembling Monolayers.- Kinase Inhibitor Profiling using Chemoproteomics.- Covalent Crosslinking of Kinases with Their Corresponding Peptide Substrates.- Receptor Tyrosine Kinase Inhibitor Profiling using Bead-based Multiplex Sandwich Immunoassays.- Monitoring PhosphoproteomicResponse To Targeted Kinase Inhibitors Using Reverse-Phase Protein Microarrays.- Measuring Phosphorylation Specific Changes in Response to Kinase Inhibitors in Mammalian Cells Using Quantitative Proteomics.- Investigation of Acquired Resistance to EGFR-Targeted Therapies in Lung Cancer Using cDNA Microarrays.

From the reviews:"This well-organized book is highly recommended to those who are interested in kinase inhibitors in both basic research and clinical practice. It is intended to provide an easily accessible collection of methods and strategies in the discovery and development of kinase inhibitors for research and clinical applications. ... chapters include a background and introduction, a list of materials required, and a detailed step-by-step description of the methods including highlights of key steps in the procedure." (Thomas L. Pazdernik, Doody's Book Reviews, March, 2012)