Immunoregulation in Inflammatory Bowel Diseases - Current Understanding and Innovation

- List of principal contributors
- List of chairpersons
- Preface

SECTION I: ADVANCES IN THE PATHOGENESIS OF INFLAMMATORY BOWEL DISEASE
1 Innate immune responses in inflammatory bowel disease
2 The adaptive immune responses in inflammatory bowel disease.
3 Relevance of bacteria in the pathogenesis of inflammatory bowel disease
4 Taking a toll on MD-2 in inflammatory bowel disease.-SECTION II: OPTIMIZATION IN THERAPY THROUGH IMPROVED DISEASE CLASSIFICATION?
5 Classification of inflammatory bowel disease can only be based on the clinical phenotype
6 Use of serology and genetics to differentiate inflammatory bowel disease phenotypes
7 Do biomarkers help to optimize therapy in inflammatory bowel disease?

SECTION III: CONVENTIONAL IMMUNOMODULATOR THERAPY
8 State-of-the-art therapy in accordance with guidelines
9 Increased risk of morbidity associated with immunomodulatory treatment in patients with inflammatory bowel diseases
10 Can immunomodulatory therapy be improved by metabolite measurement and combination therapy?

SECTION IV: RELEVANCE OF BIOLOGICS
11 Top-down therapy for inflammatory bowel disease
12 "Step-up'" versus `"top-down'" strategies in inflammatory bowel disease - what do we know in 2006?
13 Importance of mucosal healing in Crohn's disease and ulcerative colitis
14 State-of-the-Art Lecture: Distinct antibacterial-defensin deficiencies in small intestinal and colonic Crohn's disease

SECTION V: NEW THERAPEUTIC APPROACHES (PART I)
15 Oligonucleotides - new therapeutic approaches
16 Probiotics in inflammatory bowel disease
17 Helminth ova therapy for inflammatory bowel disease
18 Retarded release phosphatidylcholine: a new therapeutic option for ulcerative colitis
19 Topical steroids - rectal application

SECTION VI: NEW THERAPEUTIC APPROACHES (PART II)
20 Apheresis
21 The evolving understanding and therapy of Crohn's disease: innate immunity and sargramostim (GM-CSF) 2
2.-Immunosuppression with tacrolimus, everolimus and

From the reviews:"This book ... reviews established and emerging concepts in the diagnosis and treatment of IBD and reflects the recent advances in knowledge about the pathophysiology of Crohn's disease and ulcerative colitis. ... the book is 'essential reading' aimed at 'both basic scientist and clinicians'." (Willem JS de Villiers, Doody's Review Service, March, 2009)