Genes, Development and Cancer

- Background

- Invention of the cis-trans test for position effects

- Position pseudoalleles

- The bithorax pseudoalleles and the concept of developmental control

- Gene evolution by tandem duplication

- From cisvection to transvection

- Extending the bithorax pseudoallelic series

- Genetic versus functional models

- From genes to gene complexes

- Developmental genetics

- Gain-of-function and loss-of-function alleles, and the operon model

- Genetic mosaics: spatial and temporal aspects of bithorax function

- The 1978 paper: a paradigm for the genetic control of development

- Trans- acting regulators: positive and negative control of the homeotic complexes

- Cis-regulation within the BX-C: the rules of engagement

- Positional cloning of the BX-C

- Completing the bithorax mutant series

- The molecular basis of developmental control

- Bithorax and the evolution of sexually dimorphic traits

- DNA sequence motifs in the cis- regulatory regions of the BX-C

- Evolution of the HOX complexes

- Genetic and somatic effects of ionizing radiation

- The political and social context

- Leukemia and ionizing radiation

- Political fallout

- Thyroid radiation doses from weapons fallout

- Best estimates of risk: leukemia in populations exposed to low doses of radiation

- Estimates of lung cancer risk: the Batelle beagles