Essentials of Blood Product Management in Anesthesia Practice

The History of Blood Transfusions

Modern Blood Banking

Component Therapy and Whole Blood: Packed Red Blood Cells, Fresh Frozen Plasma, Cryoprecipitate, washed and or radiated red cells

The Coagulation System and Clot Stability

Fibrinolysis- Tranexamic Acid and Aminocaproic Acid.

Hypercoagulation and Thrombotic Disorders: TTP, Factor 5 Leiden, Phospholipid Syndrome, Anti-thrombin 3, hypereosinophils, oxidative stress, cancer.

Diseases or Conditions of Platelet Dysfunction

The Massive Transfusion ProtocolNew Biologicals to Assist Clotting- Riastap, Prothrombin Concentrates. Antithrombin3, Fibrogammin and factor13, Fibrosupernatant, Fibrinogen Concentrates, Recombinant Factor 7, DDAVP, Octaplast G., Factor 10A, KCentra



Biologicals that Inhibit Clot generation -The Heparins, Factor 10A inhibitors, rivaroxaban, apixaban, dabigatran,

Point of Care Testing and Goal Directed Therapy- Thromboelastography, ROTEM, Platelet function analyzer, stat-PT, thrombin generation assays, multi-electro-aggregometry, OHP (Overall hemostatic potential assay), ACT.

Complications of Blood Transfusions: TRALI, TACO, Blood type mismatch, infection

Diseases of the Coagulation System- Hemophilia, VonWillebrand Disease, Cryoglobulinemia, Inborn Errors of Factor Synthesis

Blood Conservation Strategies and Bloodless Surgery- normovolemic hemodilution, cell saver,Bridges to Transfusion when blood is not immediately available.



Artificial Blood

Preoperative correction of anemia

Blood Deployment in Natural Disasters and the Military in Combat

Commonly prescribed medications that affect clotting-anti-depressants, NSAIDS, ASA

Anesthesia for the severe trauma patient- new evidence from new trials

Old blood vs. new blood- Is storage injury a concern?

Vascular Endothelial dysfunction and inflammatory states

Liberal or restrictive blood transfusions

Corey Scher MDClinical Professor of AnesthesiologyNew York University School of MedicineBellevue Hospital Center New York, NY Alan David Kaye MD, PhD Vice-Chancellor of Academic Affairs, Chief Officer, and Provost Tenured Professor, Departments of Anesthesiology and Pharmacology, Toxicology, and NeurosciencesLSU School of MedicineShreveport, LAUSA Henry Liu MDProfessor of Anesthesiology & Perioperative MedicineMilton S. Hershey Medical CenterPenn State University College of MedicineHershey, PA USA Seth Perleman MDAssociate Professor of AnesthesiologyNew York University School of MedicineLangone Medical CenterNew York University School of MedicineNew York, NYUSASarah Leavitt MDAssistant ProfessorDepartment of AnesthesiologyNYU Langone Medical CenterBellevue HospitalNew York, NYUSA