Central Functions of the Ghrelin Receptor
(Sprache: Englisch)
The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism,...
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Klappentext zu „Central Functions of the Ghrelin Receptor “
The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others. The functions of the ghrelin receptor in the central nervous system are numerous and are still being explored. In this book we specifically focus on the various roles of the ghrelin receptor in the central nervous system. In a first set of chapters, the book will focus on the discovery and the properties of this intriguing constitutively active G-protein coupled receptor, on its multiple intracellular transduction mechanisms and the various subtypes of the currently known ghrelin receptor complexes. Next, the book will elaborate on the mitochondrial mechanisms regulated by the ghrelin receptor, its role in feeding and drug addictive mechanisms, memory, sleep and arousal. The final chapters focus on the potential of this receptor as a target for the treatment of neurological disorders including Parkinson's disease, epilepsy, anxiety and depression.
Inhaltsverzeichnis zu „Central Functions of the Ghrelin Receptor “
Part 1: The ghrelin receptor isoformsChapter 1: Constitutive activity of the ghrelin receptor
Jacek Mokrosi?ski, Andreas Nygaard Madsen, Birgitte Holst
Chapter 2: Homodimerization and heterodimerization of the ghrelin receptor
Alessandro Laviano, Alessia Mari
Part 2: Mechanisms of ghrelin's action
Chapter 3: The role of the ghrelin receptor in appetite and energy metabolism
Zane Andrews
Chapter 4: The vagus nerve and ghrelin function
Yukari Date
Part 3: Ghrelin receptors in food and drug addictive mechanisms
Chapter 5: Central Ghrelin Receptors and Food Intake
Mario Perello, Jesica Raingo
Chapter 6: Ghrelin receptors a novel target for obesity
Harriët Schellekens, Timothy G. Dinan, John F. Cryan
Chapter 7: Ghrelin receptor antagonism as a potential therapeutic target for alcohol use disorders: a preclinical perspective
Elisabet Jerlhag, Jörgen A. Engel
Chapter 8: Clinical Research on the Ghrelin Axis and Alcohol Consumption
Allison A. Feduccia, Lorenzo Leggio
Part 4: Ghrelin plays a role in various physiological and pathophysiological brain functions
Chapter 9: Ghrelin and Sleep Regulation
Éva Szentirmai, Levente Kapás
Chapter 10: Ghrelin and Memory
Nicolas Kunath, Martin Dresler
Chapter 11: Ghrelin receptors and Epilepsy
Jeanelle Portelli, Ann Massie, Jessica Coppens, Ilse Smolders
Chapter 12: Ghrelin plays a role in various physiological and pathophysiological brain functions
Sarah J. Spencer
Chapter 13: Ghrelin and Parkinson's Disease
Marcus M. Unger, Wolfgang H. Oertel
Bibliographische Angaben
- 2014, 2014, XVII, 214 Seiten, 7 farbige Abbildungen, Masse: 16,2 x 24,2 cm, Gebunden, Englisch
- Herausgegeben: Jeanelle Portelli, Ilse Smolders
- Verlag: Springer, Berlin
- ISBN-10: 1493908227
- ISBN-13: 9781493908226
Sprache:
Englisch
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