Angiogenesis

History of Angiogenesis.- Angiogenesis and Vascular Remodeling: Biology and Architecture of the Vasculature.- Endothelial Cell Activation.- Pericytes, the Mural Cells of the Microvascular System.- Matrix Metalloproteinases and Their Endogenous Inhibitors.- Integrins in Angiogenesis.- Fibroblast Growth Factor-2.- Vascular Permeability Factor/Vascular Endothelial Growth Factor.- Platelet-derived Growth Factor.- Angiopoietins and Tie Receptors.- Basement Membrane-derived Inhibitors of Angiogenesis.- Endostatin and Angiostatin.- Thrombospondins.- Overview of Angiogenesis during Tumor Growth.- Hypoxic Regulation of Angiogenesis by HIF-1.- Regulation of Angiogenesis by von Hippel Lindau Protein and HIF2.- Nitric Oxide in Tumor Angiogenesis.- VEGF Signal Transduction in Angiogenesis.- Delta-like Ligand 4/Notch Pathway in Tumor Angiogenesis.- Immune Cells and Inflammatory Mediators as Regulators of Angiogenesis.- Contribution of Endothelial Progenitor Cells to the Angiogenic Process.- The Cancer Stem Cell Model.- Targeting the Tumor Microenvironment (Stroma).- Normalization of Tumor Vasculature and Microenvironment.- Targeted Drug Delivery to the Tumor Neovasculature.- Models for Angiogenesis.- Surrogates for Clinical Development.- Imaging of Angiogenesis.- Tumor Endothelial Markers.- Overview and Clinical Applications of VEGF-A.- Protein Tyrosine Kinase as Antiangiogenic Agents.- Therapeutic Strategies that Target the HIF System.- The Clinical Utility of Bevacizumab.- Development of Thalidomide and its IMiD Derivatives.- TNP-470: The Resurrection of One of the First Angiogenesis Inhibitors.- Clinical Development of VEGF Trap.- Recent Advances in Angiogenesis Drug Development.- Combination of Angiogenic Therapy with other Anticancer Therapies.- Immunotherapy of Angiogenesis with DNA Vaccines.- Challenges of Antiangiogenic Therapy of Tumors.- Pharmacogenetics of Antiangiogenic Therapy.- Angiogenesis in the Central Nervous System.-Lymphatic Vascular System and

Dr. Judah Folkman (1933-2008) was considered the "father of angiogenesis." Because of Folkman's discovery and research, the possibilities of angiogenic therapy have broadened beyond cancer to many noncancerous diseases.

Angiogenesis: An Integrative Approach from Science to Medicine is a comprehensive, concise summary of tumor angiogenesis. It is an up-to-date and authoritative reference for the angiogenesis field as it relates to oncology. This book represents the first collection in a volume of which Folkman is co-editor. Folkman has authored nearly 400 original papers and more than 100 book chapters.

From the reviews:

"Folkman ... assembled his final masterpiece in Angiogenesis, a book he coedited with William Figg. ... The text, written by well-known contributors to the field, is complemented by a large number of helpful schematics and photomicrographs. The references are extensive and encyclopedic. In summary, if I were to have a single textbook on this subject on my bookshelf, this book would have no competition. ... this will be the authoritative text on angiogenesis for many years to come." (Douglas W. Losordo, New England Journal of Medicine, Vol. 359 (23), December, 2008)

From the reviews:

"Folkman ... assembled his final masterpiece in Angiogenesis, a book he coedited with William Figg. ... The text, written by well-known contributors to the field, is complemented by a large number of helpful schematics and photomicrographs. The references are extensive and encyclopedic. In summary, if I were to have a single textbook on this subject on my bookshelf, this book would have no competition. ... this will be the authoritative text on angiogenesis for many years to come." (Douglas W. Losordo, New England Journal of Medicine, Vol. 359 (23), December, 2008)