Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis

Pharmacokinetics: Physiological and Biochemical Basis.- Predicting Oral Drug Absorption in Humans: A Macroscopic Mass Balance Approach for Passive and Carrier-Mediated Compounds.- Pharmacokinetics of Linear Reversible Metabolic Systems.- Pharmacokinetic Models for Anticancer and Antiviral Drugs following Administration as Novel Drug Delivery Systems.- The Significance of Marked "Universal" Dependence of Drug Concentration on Blood Sampling Site in Pharmacokinetics and Pharmacodynamics.- Pharmacodynamics: Measurements and Models.- Physiological Alternatives to the Effect Compartment Model.- Pharmacokinetics/Dynamics of Corticosteroids.- Variability in Human Cardiovascular Pharmacodynamics.- Pharmacodynamic Modeling of Thiopental Depth of Anesthesia.- Pharmacometrics: Modeling, Estimation and Control.- Residence Time Distributions in Pharmacokinetics: Behavioral and Structural Models.- Pharmacokinetic Parameter Estimation with Stochastic Dynamic Models.- Relationships between Intra- or Interindividual Variability and Biological Covariates: Application to Zidovudine Pharmacokinetics.- On the Single-Point, Single-Dose Problem.- Application of Stochastic Control Theory to Optimal Design of Dosage Regimens.- Pharmacotherapeutics: Measurement, Control and Delivery.- Development of a Fiber Optic Sensor for Detection of General Anesthetics and Other Small Organic Molecules.- A Bayesian Kinetic Control Strategy for Cyclosporin in Renal Transplantation.- Targeted Systemic Exposure for Pediatric Cancer Therapy.- Targeting the Effect Site With a Computer Controlled Infusion Pump.- Contributors.- Participants.