Adherens Junctions: from Molecular Mechanisms

1. An introduction to adherens junctions: from molecular mechanisms to tissue development and disease; Tony Harris

Part I: How AJs evolved2. Evolution of the cadherin-catenin complex; Hiroki Oda

Part II: How cadherins and catenins interact to assemble AJs3. The three-dimensional structure of the cadherin-catenin complex; Noboru Ishiyama and Mitsuhiko Ikura4. Biophysics of cadherin adhesion; Deborah Leckband and Sanjeevi Sivasankar5. Adherens junction assembly; Sergey Troyanovski

Part III: How AJs interface with other cellular machinery6. The cytoskeleton and classical cadherin adhesions; Siew Ping Han and Alpha Yap7. Immunoglobulin superfamily receptors and adherens junctions; Yohei Shimono, Yoshiyuki Rikitake, Kenji Mandai, Masahiro Mori and Yoshimi Takai8. Signaling from the adherens junction; Abbye McEwen, David Escobar and Cara Gottardi9. Adherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recycling; Benjamin Nanes and Andrew Kowalczyk

Part IV: How AJs affect cell behaviour and multicellular development10. Adherens junctions during cell migration; Sandrine Etienne-Manneville11. Adherens junctions and cadherins in Drosophila development; Annalisa Letizia and Marta Llimargas12. Adherens junctions in C. elegans embryonic morphogenesis; Stephen Armenti and Jeremy Nance13. Cadherin function during Xenopus gastrulation; Rudolf Winklbauer14. Adherens junctions in mammalian development, homeostasis and disease: lessons from mice; Barbara Boggetti and Carien Niessen

Part V: How AJs affect tissue homeostasis and disease15. Adherens junctions and stem cells; Terry Lechler16. Adherens junctions and cancer; Valeri Vasioukhin17. Adherens junctions and pathogens entry; Georgios Nikitas and Pascale Cossart

Index