Variant Haemoglobins (ePub)

Variant Haemoglobins - A Guide to Identification is
based on the premise that any single diagnostic technique offers
only a very provisional identification of a variant haemoglobin. In
routine diagnostic practice two techniques are needed as a minimum,
with the results being interpreted in the light of the clinical
details, blood count, blood film and ethnic origin. This book
covers 150 normal and variant haemoglobins that have been studied
and carefully documented.

Variant Haemoglobins has four introductory chapters
followed by an invaluable atlas. The introductory chapters
cover

* the genetics of haemoglobin synthesis

* the principles of tests employed for identification

* common haemoglobins of major clinical or diagnostic
importance

* thalassaemias and related conditions

The atlas section comprises 170 full colour pages in which each
variant haemoglobin or combination of haemoglobins is illustrated
by cellulose acetate electrophoresis at alkaline pH, agarose gel
electrophoresis at acid pH, isoelectric focusing and one or more
HPLC traces. For ease of reference, the atlas pages are arranged
according to the retention time of each haemoglobin on HPLC, this
becoming increasingly the primary technique employed in haemoglobin
identification.

Bringing a mix of necessary scientific expertise and clinical
knowledge, each author has more than 30 years experience in the
diagnosis of variant haemoglobins.

Providing otherwise unavailable information, this unique and
practical guide

* is illustrated with over 700 high quality colour digital images
plus flow charts and line diagrams

* covers common and important haemoglobin variants, in addition
to many rarer ones

* is an essential reference source for diagnosis in the
haematology laboratory

A remarkably useful book, Variant Haemoglobins will be
valuable for haematopathologists, clinical and laboratory
haematologists in practice and in training and all laboratory staff
involved in haemoglobinopathy diagnosis.