Free-Radical-Induced DNA Damage and Its Repair (PDF)
Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to...
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Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters.
Born in 1936, Chemistry at Heidelberg, Vienna and Karlsruhe, PhD (1964 with D. Schulte-Frohlinde) and Habilitation (1970) at Karlsruhe. Postdoc with F. S. Dainton (Leeds). 1960-1970 Nuclear Research Center Karlsruhe, 1970- 2001 Max-Planck-Institut für Strahlenchemie, Mülheim. After retirement continuing collaboration with the Leibniz-Institut für Oberflächenmodifizierung (IOM), Leipzig.
- Autor: Clemens Sonntag
- 2006, 2006, 523 Seiten, Englisch
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3540305920
- ISBN-13: 9783540305927
- Erscheinungsdatum: 20.03.2006
Abhängig von Bildschirmgrösse und eingestellter Schriftgrösse kann die Seitenzahl auf Ihrem Lesegerät variieren.
- Dateiformat: PDF
- Grösse: 13 MB
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