Drug Delivery Applications of Noninvasive Imaging (PDF)

Cost-effective strategies for designing novel drug delivery
systems that target a broad range of disease conditions

In vivo imaging has become an important tool for the
development of new drug delivery systems, shedding new light on the
pharmacokinetics, biodistribution, bioavailability, local
concentration, and clearance of drug substances for the treatment
of human disease, most notably cancer. Written by a team of
international experts, this book examines the use of quantitative
imaging techniques in designing and evaluating novel drug delivery
systems and applications.

Drug Delivery Applications of Noninvasive Imaging offers
a full arsenal of tested and proven methods, practices and
guidance, enabling readers to overcome the many challenges in
creating successful new drug delivery systems. The book begins with
an introduction to molecular imaging. Next, it covers:

* In vivo imaging techniques and quantitative
analysis

* Imaging drugs and drug carriers at the site of action,
including low-molecular weight radiopharmaceuticals, peptides and
proteins, siRNA, cells, and nanoparticles

* Applications of imaging techniques in administration routes
other than intravenous injection, such as pulmonary and oral
delivery

* Translational research leading to clinical applications

* Imaging drug delivery in large animal models

* Clinical applications of imaging techniques to guide drug
development and drug delivery

Chapters are based on a thorough review of the current
literature as well as the authors' firsthand experience working
with imaging techniques for the development of novel drug delivery
systems.

Presenting state-of-the-technology applications of imaging in
preclinical and clinical evaluation of drug delivery systems,
Drug Delivery Applications of Noninvasive Imaging offers
cost-effective strategies to pharmaceutical researchers and
students for developing drug delivery systems that accurately
target a broad range of disease conditions.