Cancer Chemoprevention / Cancer Drug Discovery and Development (PDF)

Much progress has been made in discovering and developing agents that have promise, or have already been successfully used, to treat precancerous conditions or inhibit carcinogenesis. In Cancer Chemoprevention, Volume 2: Strategies for Cancer Chemoprevention, leading chemopreventives investigators comprehensively describe the exciting methodologies that are accelerating progress in the chemoprevention field and review the state of clinical development of preventive agents in the major human cancer target organs. The authors provide sound guidelines for cancer chemopreventive drug development, detailing general strategies and methods for drug discovery, preclinical efficacy, characterization of precancers, safety evaluation of clinical cohorts, and clinical trial design. Additional chapters address strategies for and the status of chemopreventive agent development in multiple myeloma and cancers of the prostate, breast, lung, colon, bladder, head and neck, esophagus, pancreas, ovary, endometrium, cervix, skin, and liver. The emphasis is on documenting the characterization and application of reliable biomarkers during chemopreventive drug development. Highlights include an elegant approach to identifying chemopreventive agents in natural products, the development of preclinical models for evaluating potential chemopreventive agents, the genomics and proteomics of potential applications, and approaches for determining which populations will likely benefit from chemopreventive intervention. A companion volume, Promising Cancer Chemopreventive Agents, comprehensively surveys those agents that have promise, or have already been successfully used, to treat precancerous conditions or inhibit carcinogenesis. A value-added compact disk containing a companion ebook version of Cancer Chemoprevention, Volume 2: Strategies for Cancer Chemoprevention is included for downloading and use in the reader's PC or PDA.

Up-to-date and highly practical, Cancer Chemoprevention, Volumes 1 & 2, offer oncologists, pharmacologists, medicinal chemists, and toxicologists a comprehensive reference survey on the identification of those promising cancer chemopreventive agents that will help stimulate further research and the development of novel approvable drugs.