Total Synthesis of Galbulimima Alkaloids: Himgaline and GB13; .
(Sprache: Englisch)
For thousands of years nature has played an important role in providing mankind with life-saving drugs. Several natural products have been clinically approved and they continue to remain as valuable medicines. However, in cases where the supply of an active...
Leider schon ausverkauft
versandkostenfrei
Buch (Kartoniert)
Fr. 127.00
inkl. MwSt.
- Kreditkarte, Paypal, Rechnungskauf
- 30 Tage Widerrufsrecht
Produktdetails
Produktinformationen zu „Total Synthesis of Galbulimima Alkaloids: Himgaline and GB13; . “
Klappentext zu „Total Synthesis of Galbulimima Alkaloids: Himgaline and GB13; . “
For thousands of years nature has played an important role in providing mankind with life-saving drugs. Several natural products have been clinically approved and they continue to remain as valuable medicines. However, in cases where the supply of an active natural product is limited, total synthesis is often the only means by which sufficient quantities could be generated for therapeutic use. Additionally, such a process could unveil novel pharmacophores which could serve as templates for designing new drugs.Himbacine, himgaline, and GB13 belong to a family of alkaloids isolated from the bark of a rain forest tree, Galbulimima belgraveana. While himbacine has been extensively studied for its antimuscarinic activity, the biological properties of its more complex congeners remain unexplored. This book describes total syntheses of both the enantiomers of himgaline and GB13. Key manipulations involved a Diels-Alder reaction, an aldol-type cascade cyclization, an aza-Michael reaction, and a hydroxyl-directed stereoselective ketone reduction. This synthetic achievement paves the way for future exploration of the medicinal value of compounds described herein and other related natural products.
Autoren-Porträt von U. Shah, Unmesh Shah
Shah, U.Unmesh Shah - Ph.D. in Chemistry from Stevens Institute of Technology, NJ, USA. Currently employed as a Research Scientist in the medicinal chemistry department at Schering-Plough Research Institute, NJ. Author and co-author on several patents and publications in peer reviewed journals.Chackalamannil, S.
Unmesh Shah - Ph.D. in Chemistry from Stevens Institute of Technology, NJ, USA. Currently employed as a Research Scientist in the medicinal chemistry department at Schering-Plough Research Institute, NJ. Author and co-author on several patents and publications in peer reviewed journals.Ganguly, A. K.
Unmesh Shah - Ph.D. in Chemistry from Stevens Institute of Technology, NJ, USA. Currently employed as a Research Scientist in the medicinal chemistry department at Schering-Plough Research Institute, NJ. Author and co-author on several patents and publications in peer reviewed journals.
Bibliographische Angaben
- Autoren: U. Shah , Unmesh Shah
- 2008, 244 Seiten, Masse: 15 x 22 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag Dr. Müller e.K.
- ISBN-10: 3639004825
- ISBN-13: 9783639004823
Sprache:
Englisch
Kommentar zu "Total Synthesis of Galbulimima Alkaloids: Himgaline and GB13; ."
0 Gebrauchte Artikel zu „Total Synthesis of Galbulimima Alkaloids: Himgaline and GB13; .“
Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
---|
Schreiben Sie einen Kommentar zu "Total Synthesis of Galbulimima Alkaloids: Himgaline and GB13; .".
Kommentar verfassen