Quantitative Molecular Pharmacology and Informatics in Drug Discovery
(Sprache: Englisch)
Recent years have seen the emergence of the new field of bioinformatics which, together with new techniques in molecular biology, has revolutionized drug discovery.
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Recent years have seen the emergence of the new field of bioinformatics which, together with new techniques in molecular biology, has revolutionized drug discovery.
Klappentext zu „Quantitative Molecular Pharmacology and Informatics in Drug Discovery “
Quantitative Molecular Pharmacology and Informatics in Drug Discovery Michael Lutz, Section Head, Cheminformatics Group and Terry Kenakin, Principal Research Scientist, Glaxo Wellcome Research and Development, Research Triangle Park, NC, USA Quantitative Molecular Pharmacology and Informatics in Drug Discovery combines pharmacology, genetics and statistics to provide a complete guide to the modern drug discovery process. The book discusses the pharmacology of drug testing and provides a detailed description of the statistical methods used to analyze the resulting data. Application of genetic and genomic tools for identification of biological targets is reviewed in the context of drug discovery projects. Covering both the theoretical principles upon which the techniques are based and the practicalities of drug discovery, this informative guide.* outlines in step-by-step detail the advantages and disadvantages of each technology and approach and links these to the type of chemical target being sought after in the drug discovery process; and,
* provides excellent demonstrations of how to use powerful pharmacological and statistical tools to optimize high-throughput screening assays.
Written by two internationally known and well-regarded experts, this book is an essential reference for research and development scientists working in the pharmaceutical and biotechnology industries. It will also be useful for postgraduates studying pharmacology and applied statistics.
Inhaltsverzeichnis zu „Quantitative Molecular Pharmacology and Informatics in Drug Discovery “
Drug DiscoveryMeasurement of Drug Affinity
Efficacy
Pharmacological Assays Used in Screening for Therapeutic Ligands
Finding the Optimal Assay Format for the Chemical Target
Mathematical and Statistical Framework for Problems in Drug Discovery
Statistical Methods for Target Identification and Validation
Experimental Design
Analysis and Interpretation of Data
Index
Bibliographische Angaben
- Autoren: Michael Lutz , Terry Kenakin
- 1999, 1. Auflage, XVIII, 410 Seiten, Masse: 15,7 x 23,5 cm, Gebunden, Englisch
- Verlag: Wiley & Sons
- ISBN-10: 0471988618
- ISBN-13: 9780471988618
- Erscheinungsdatum: 28.12.1999
Sprache:
Englisch
Rezension zu „Quantitative Molecular Pharmacology and Informatics in Drug Discovery “
"...a timely and important book..." "I recommend this book to pharmaceutical company statisticians..."--Biometrics, September 2000"...covers a tremendous amount of ground....I recommend this book to pharmaceutical statisticians..."--Technometrics, 2000
Pressezitat
"...a timely and important book..." "I recommend this book to pharmaceutical company statisticians..."--Biometrics, September 2000
"...covers a tremendous amount of ground....I recommend this book to pharmaceutical statisticians..."
--Technometrics, 2000
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