High Density Lipoproteins, Dyslipidemia, and Coronary Heart Disease

Introduction: HDL, Dyslipidemia, and Coronary Heart Disease.- Regulation of Apolipoprotein A-I Gene Expression, Synthesis, and Function.- The Many and Varied Functions of HDL.- HDL Particle Composition, Proteomics, and Metabolism.- HDL Structure, Function, and Anti-inflammatory Properties.- Human ApoA-I Deficiency.- Human ApoA-I Variants.- Cellular Cholesterol Efflux 1: ABCA 1 Function and Deficiency.- Cellular Cholesterol Efflux 2: ABCG1 Function.- Cellular Cholesterol Efflux 3: ABCA1, ABCG1 and HDL Particle Interaction.- Cholesterol Esterification and Human LCAT Deficiency.- Effects of Lipoprotein Lipase and Hepatic Lipase Deficiency on HDL Metabolism.- Cholesteryl Ester Transfer Protein (CEPT) and Human CETP Deficiency.- HDL Metabolism and Scavenger Receptor B1.- The Genetics of HDL.- Effects of Nutrition and Excersize on HDL Metabolism.- Effects of Alcohol on HDL Metabolism.- Effects of Estrogens on HDL Metabolism.- Efects of Niacin on HDL Metabolism.- Effects of Statins on HDL Metabolism.- Effects of Fibrates on HDL Metabolism.- Effects of Cholesterol Ester Transfer Protein Inhibition on HDL Metabolism.- Oral and HDL Infusion Therapy to Enhance Reverse Cholesterol Transport.- Conclusions.