Epigenetic Targets in Drug Discovery
(Sprache: Englisch)
Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease. The first part of the book surveys current...
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Klappentext zu „Epigenetic Targets in Drug Discovery “
Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease. The first part of the book surveys current methodologies for finding and validating drug candidates that act via epigenetic mechanisms. The second part systematically surveys known and suspected drug targets within the epigenetic machinery, including the discovery and development of vorinostat, the first marketed epigenetic drug.
Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease.
The first part of the book surveys current methodologies for finding and validating drug candidates that act via epigenetic mechanisms. The second part systematically surveys known and suspected drug targets within the epigenetic machinery, including the discovery and development of vorinostat, the first marketed epigenetic drug.
The first part of the book surveys current methodologies for finding and validating drug candidates that act via epigenetic mechanisms. The second part systematically surveys known and suspected drug targets within the epigenetic machinery, including the discovery and development of vorinostat, the first marketed epigenetic drug.
Inhaltsverzeichnis zu „Epigenetic Targets in Drug Discovery “
PART I: INTRODUCTIONIntroduction to Epigenetics
PART II: METHODOLOGIES
Structural Biology of Epigenetic Targets
Computer-based Approaches
Mass Spectrometry Approaches
Cell-based Assays for Hit Validation
Chromatin Immunoprecipitation
PART III: EPIGENETIC TARGET CLASSES
HDAC Inhibitors: The Development of Vorinostat
Sirtuins as Drug Targets in Life Span Extension and Prevention of Neurodegeneration
Protein Arginine Methyltransferases (PRMTs) as Novel Drug Targets in Tumor Therapy
LSD1 and JMJD Demethylases
Histone Acetyltransferase Inhibitors
DNA Methylases as Drug Targets
Autoren-Porträt
Wolfgang Sippl is the head of Pharmaceutical and Medicinal Chemistry at the Martin-Luther University of Halle-Wittenberg (Germany). He obtained his Ph.D. in pharmaceutical chemistry at University of Düsseldorf and was a post-doctoral fellow at the Université Louis-Pasteur in Strasbourg (France), where he worked with Camille G. Wermuth. He then took a senior researcher position in Düsseldorf before moving to the University of Halle-Wittenberg as a full professor in 2003. His main interests are focussed on medicinal chemistry, computational chemistry and drug designManfred Jung is Professor for Pharmaceutical and Medicinal Chemistry at the Albert-Ludwigs University of Freiburg (Germany). He obtained a Ph. D. in Pharmaceutical Chemistry from the University of Marburg, working subsequently as a postdoctoral fellow with T. Durst at the University of Ottawa (Canada). In 1994 he started his own group at the Institute of Pharmaceutical Chemistry at the University of Münster and in 2003 he moved to Freiburg to his current position. His main research focus is the synthesis of enzyme inhibitors and in-vitro assay development in the field of histone modifying enzymes.
Bibliographische Angaben
- 2009, XVI, 298 Seiten, 15 farbige Abbildungen, 90 Schwarz-Weiss-Abbildungen, Masse: 17,9 x 24,9 cm, Gebunden, Englisch
- Herausgegeben: Wolfgang Sippl, Manfred Jung, Raimund Mannhold
- Verlag: Wiley-VCH
- ISBN-10: 3527323554
- ISBN-13: 9783527323555
- Erscheinungsdatum: 24.06.2009
Sprache:
Englisch
Rezension zu „Epigenetic Targets in Drug Discovery “
"The book provides an overview about the ‘current methodologies for finding and validating drug candidates acting on epigenetic mechanisms.'" (RoSearch, December 2010) "Provides a fresh overview within the epigenetic area. ... Effective in combining basic knowledge, methodologies, and drug discoveries in a field that is expanding daily. To the best of my knowledge, this is the first compendium that has these characteristics." (ChemMedChem, 2010) "Authoritative and comprehensive." (ChemBioChem, October 2009)
Pressezitat
"The book provides an overview about the 'current methodologies for finding and validating drug candidates acting on epigenetic mechanisms. " ( RoSearch , December 2010)"Provides a fresh overview within the epigenetic area. ... Effective in combining basic knowledge, methodologies, and drug discoveries in a field that is expanding daily. To the best of my knowledge, this is the first compendium that has these characteristics." ( ChemMedChem , 2010)
"Authoritative and comprehensive." ( ChemBioChem , October 2009)
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