Drugs During Pregnancy
Methodological Aspects
(Sprache: Englisch)
This book addresses methodological aspects of epidemiological studies on maternal drug use in pregnancy. Discussing the existing sources of error and how they can produce incorrect conclusions, it examines various epidemiological techniques and assesses...
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Klappentext zu „Drugs During Pregnancy “
This book addresses methodological aspects of epidemiological studies on maternal drug use in pregnancy. Discussing the existing sources of error and how they can produce incorrect conclusions, it examines various epidemiological techniques and assesses their strengths and weaknesses. These refer both to the identification of outcomes (with special emphasis on congenital malformations) and to the types of exposure (drug use). Further, the book discusses the problem of confounding and how to handle it, and provides a simple introduction to statistics. Special situations, e.g. different types of parental exposure, are examined. Lastly, the book discusses pharmacovigilance and the information problem, concluding with a short list of aspects to consider when one wants to evaluate a published paper in the field.
Though the book is primarily intended for pharmacologists, gynecologists and obstetricians, it will benefit all doctors working in perinatal care.
Inhaltsverzeichnis zu „Drugs During Pregnancy “
Introduction.- The alert clinician.- Thalidomide.- Anticonvulsants.- Warfarin.- Drugs for thyrotoxicosis.- Retinoids.- Mycophenolate mofetil.- Animal experiments and adverse drug reaction reports.- Animal experiments.- Adverse drug reaction reports.- Some epidemiological principles.- Population studies.- Case-control studies.- Cohort studies.- Comparison between case-control and cohort studies.- Nested case-control studies.- The sibling approach.- Pregnancy outcomes with the exception of congenital malformations.- Maternal pregnancy complications.- Spontaneous abortion.- Stillbirth and infant death.- Gestational duration and birth weight.- Intrauterine growth.- Other body dimensions.- Perinatal morbidity.- Long term effects.- Congenital malformations.- Definition.- Major and minor malformations.- Single and multiple malformations.- .- Causes of congenital malformations.- Sources of information on malformations.- Prenatal diagnosis and induced abortion.- Grouping of congenital malformations .- Identification of maternal use of drugs.- Questionnaires or interviews in a case-control setting.- Prospective randomized studies.- Teratology Information Services (TIS).- Prospective studies of pregnant populations.- Pregnancy registers.- The Swedish Medical Birth Register.- Prescription registers.- The effect of errors in drug exposure ascertainment.- Information on dosage of drugs used .- The problem of confounding.- Mediating factors should not be adjusted for.- Some common and sometimes important confounders.- Interaction between confounders.- Residual confounding.- Statistics .- Risk estimates.- Is the odd ratio or risk ratio statistically significant?.- The confidence interval.- Expected numbers.- Dealing with confounders.- Survival analysis.- Power analysis.- The p value and mass significance.- Lumping or splitting? Lumping or splitting of drug
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exposures.- Lumping or splitting of outcomes.- Paternal use of drugs.- Timing of drug use and effects on the embryo or fetus.- Exposures before conception.- Period of organogenesis, first trimester exposure.- Exposure after the first trimester.- Repeated studies and meta-analysis.- Pharmacovigilance.- Information on the risk with drug use during pregnancy.- Concluding remarks.
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Autoren-Porträt von Bengt Källén
Bengt Källén is a professor emeritus of embryology at Lund University in Sweden and head of the Tornblad Institute for embryology. He has been working in birth defect epidemiology since the 1960s, and served from 1964 to 2015 as a consultant at the National Board of Health and Welfare in Stockholm, mainly focusing on the national registration of congenital malformations and analyses of reproduction outcome after exposure to various influences, including drugs. He is one of the founders of the Swedish Register of Congenital Malformations, and of the International Clearinghouse for Birth Defects Monitoring Systems. He has published ca. 400 scientific papers, including numerous articles on congenital malformations, the effects of maternal drug use during pregnancy, and in vitro fertilization.
Bibliographische Angaben
- Autor: Bengt Källén
- 2016, 1st ed. 2016, XI, 111 Seiten, 111 farbige Abbildungen, Masse: 16 x 24,1 cm, Gebunden, Englisch
- Verlag: Springer, Berlin
- ISBN-10: 3319406965
- ISBN-13: 9783319406961
Sprache:
Englisch
Pressezitat
"This book addresses the methodology involved in evaluating drug studies. It is intended to highlight issues involved in studies of drugs in pregnancy. It is short and concise and an excellent contribution. The book is written for those with an interest in obstetrical drug studies. This can be physicians, epidemiologists, and other students." (Anthony Shanks, Doody's Book Reviews, December, 2016)Kommentar zu "Drugs During Pregnancy"
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