Amino Acids, Peptides and Proteins in Organic Chemistry: 2 Amino Acids, Peptides and Proteins in Organic Chemistry

PART I: Synthesis and Chemistry of Modified Amino AcidsSYNTHESIS AND CHEMISTRY OF ALPHA, BETA-DIDEHYDROAMINO ACIDSIntroductionSynthesis of DDAAsReactions of DDAAsExperimental ProceduresSYNTHESIS AND CHEMISTRY OF ALPHA-HYDRAZINO ACIDSIntroductionSynthesisChemistryExperimental ProceduresHYDROXAMIC ACIDS: CHEMISTRY, BIOACTIVITY, AND SOLUTION- AND SOLID-PHASE SYNTHESISIntroductionChemistry, Bioactivity, and Clinical UtilitySolution-Phase Synthesis of Hydroxamic AcidsSolid-Phase Synthesis of Hydroxamic AcidsExperimental ProceduresCHEMISTRY OF ALPHA-AMINOBORONIC ACIDS AND THEIR DERIVATIVESIntroductionSynthesis of Alpha-Aminoboronic AcidsSynthesis of Alpha-Aminoboronic Acid DerivativesAsymmetric Synthesis via Alpha-Haloalkylboronic EstersSynthesis of Glycine Alpha-Aminoboronic AcidsSynthesis of Proline Alpha-Aminoboronic AcidsSynthesis of Alanine Alpha-Aminoboronic AcidsSynthesis of Ornithine Alpha-Aminoboronic AcidsSynthesis of Arginine Alpha-Aminoboronic AcidsSynthesis of Phenethyl Peptide Boronic AcidsSynthesis via Zirconocene SpeciesSynthesis and Activity of Amine-Carboxyboranes and their DerivativesSynthesis of Boron Analogs of PhosphonoacetatesCHEMISTRY OF AMINOPHOSPHONIC ACIDS AND PHOSPHONOPEPTIDESIntroductionPhysical/Chemical Properties and AnalysisSynthesis of Alpha-Aminophosphonic AcidsSynthesis of Beta-AminophosphonatesSynthesis of Gamma-Aminophosphonates and Higher HomologsPhosphono- and PhosphinopeptidesRemarks on the Practical Utility of AminophosphonatesExperimental ProceduresCHEMISTRY OF SILICON-CONTAINING AMINO ACIDSIntroductionSynthesis of Silicon-Containing Amino AcidsReactions of Silicon-Containing Amino AcidsBioactive Peptides Incorporating Silicon-Substituted Amino AcidsExperimental Procedures PART II: Amino Acid OrganocatalysisCATALYSIS OF REACTIONS BY AMINO ACIDSIntroductionAldol ReactionMannich ReactionAlpha-Amination ReactionMichael ReactionMorita-Baylis-Hillman Reactions and their Aza CounterpartMiscellaneous Amino Acid-Catalyzed

Andrew Hughes is a Reader and Head of the Department of Chemistry, La Trobe University, Melbourne, Australia. He obtained his degrees from the University of Western Australia. Post-doctoral appointments at the University of Cambridge starting 1989 included 3 years working with Professor Andrew Holmes before joining Professor Steven LeyŽs group in 1993. While at Cambridge he was appointed the Shell Research Fellow at Robinson College.